Ageing Gracefully without Chronic
Human Diseases. Is this possible? v4
By
Walter Derzko
Toronto
April 22, 2015
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Is it possible to live past 100? And
without chronic human diseases?
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Mortality 1900 vs 2010?
Why all these new 21 cent. Diseases?
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Life Expectancy
http://www.worldlifeexpectancy
.com/world-life-expectancy-map
Life expectancy in Canada (#16 )
80 = men, 84 = women;
USA (#36) 77=men, 82=women;
Ukraine (#138) 63=man,
73=women
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Top Causes of Death
• http://www.worldlifeexpectancy.com/usacause-of-death-by-age-and-gender
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
#3 Cause of Death –Your Doctor (USA)
• Doctors Are The Third Leading Cause of Death in the US, Killing 225,000
People Every Year
• July 30, 2000 |
• This article in the Journal of the American Medical Association (JAMA) is
the best article I have ever seen written in the published literature
documenting the tragedy of the traditional medical paradigm.
• This information is a followup of the Institute of Medicine report which hit
the papers in December of last year, but the data was hard to reference as
it was not in peer-reviewed journal. Now it is published in JAMA which is
the most widely circulated medical periodical in the world.
• The author is Dr. Barbara Starfield of the Johns Hopkins School of Hygiene
and Public Health and she describes how the US health care system may
contribute to poor health.
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Doctor & Hospital Caused Deaths
(USA)
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ALL THESE ARE DEATHS PER YEAR:
12,000 -- unnecessary surgery
7,000 -- medication errors in hospitals
20,000 -- other errors in hospitals
80,000 -- infections in hospitals
106,000 -- non-error, negative effects of drugs
These total to 225,000 deaths per year from
iatrogenic causes!!
Jan 16, 2015
Medical Errors
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Medical Errors
•
http://news.nationalpost.com/health/inside-canadas-secret-world-of-medical-errors-there-is-a-lot-of-lying-theres-a-lot-ofcover-up
• 23,000 Canadian Deaths
• Ontario. Estimated adverse events: 71,995
events,
• 3,561-9,143 deaths
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Top Causes of Death
Why so many heart deaths in USA south?
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Biochemical Pathways are Complex
One missing element can effect a number of pathways
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Is it possible to live past 100? And
without chronic human diseases?
YES!! eliminate excess oxidative stress and eliminate lack of essential and trace minerals
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Is it possible to live past 100? And
without chronic human diseases?
China. Man lived to be 256 yo allegedly
Born
Claimed 1677 or 1736
Sichuan, Qing Empire
Died
May 6, 1933
Sichuan, Republic of China
Cause of death
Natural causes
Known for
Extreme longevity claim and spiritual
practices by means of herbs
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Common cause?
• Is there a common denominator between all
these new, individual, seemingly unrelated 21st
century diseases?
• Cancer? Heart Disease? Alzhei er’s, Parki so ’s?
Diabetes?
• YES two underlying causes
• Free radicals or oxidative stress
• Lack of essential minerals or lack of trace
minerals
Is it possible to live past 100? And
without chronic human diseases?
• YES !
• Reduce Free Radicals and Oxidative Stress
• Most Chronic Human Diseases are triggered by excess free
radicals
• Free radicals are molecules that are the waste products of
oxygen metabolism (pro-oxidants) and damage cell walls, lipids,
proteins, DNA
• Oxygen or Nitrogen free radical molecules are missing one
electron, which needs to be paired up to be stable
• Botanical Antioxidants and antioxidant enzymes neutralise
excess free radicals
• Ukrainian scientists discovered the highest antioxidant in the
world Carbon 60 Hydrated Fullerenes
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Oxidative Stress
• It has become increasingly evident that chronic inflammation
underpins the development of many chronic diseases including
cancer, cardiovascular disease, and type 2 diabetes.
• Reactive oxygen species (ROS) are generated by normal energy
metabolism and function as important cell signaling molecules.
• In homeostatic conditions, intracellular ROS are maintained at
appropriate concentrations to fulfill these functions and any
excesses are buffered by various antioxidant enzymes and
molecules.
• If ROS production increases beyond the threshold of this buffering
capacity, these reactive species trigger uncontrolled reactions with
non-target intracellular compounds, oxidizing nucleic acids,
proteins, membrane, and other lipids.
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Oxidative Stress & Inflammation
• Normal intracellular oxidative status is reducing. As the
number of oxidized compounds rises, the intracellular
redox state of the cell begins to shift away from its
normal reducing environment and oxidative stress
ensues.
• Oxidative stress is inherently a biochemical
dysregulation of the redox status of the intracellular
environment, which under homeostatic conditions is a
reducing environment, whereas inflammation is the
biological response to oxidative stress in that the cell
initiates the production of proteins, enzymes and other
compounds to restore homeostasis.
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Oxidative Stress
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Oxidative Stress
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Oxidative Stress and Nursing Homes
•
Oxid Med Cell Longev. 2015;2015:804198. doi: 10.1155/2015/804198. Epub 2015
Mar 19.
• Relationship between Inflammation and Oxidative
Stress and Cognitive Decline in the Institutionalized
Elderly.
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Baierle M1, Nascimento SN1, Moro AM1, Brucker N1, Freitas F1, Gauer B1, Durgante
J2, Bordignon S3, Zibetti M3, Trentini CM3, Duarte MM4, Grune T5, Breusing N6,
Garcia SC1.
Author information
1Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty,
Federal University of Rio Grande do Sul, 90610 000 Porto Alegre, RS, Brazil ; PostGraduate Program in Pharmaceutical Sciences (PPGCF), Federal University of Rio
Grande do Sul, 90610 000 Porto Alegre, RS, Brazil.
2Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty,
Federal University of Rio Grande do Sul, 90610 000 Porto Alegre, RS, Brazil.
3Institute of Psychology, Federal University of Rio Grande do Sul (UFRGS), 90035
003 Porto Alegre, RS, Brazil.
4Department of Health Sciences, Lutheran University of Brazil, 97020 001 Santa
Maria, RS, Brazil.
5German Institute of Human Nutrition, 14558 Nuthetal, Germany.
6Department of Applied Nutritional Science and Dietetics, Institute of Nutritional
Medicine, University of Hohenheim, 70593 Stuttgart, Germany.
Oxidative Stress and Nursing Homes
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Abstract
Objective.
Cognitive impairment reduces quality of life and is related to vascular and neurodegenerative disorders. However,
there is also a close relationship between these diseases and oxidative stress. Thus, the purpose of this study was
to assess whether inflammation and oxidative damage are associated with low cognitive performance in the
elderly with different housing conditions.
Methods. The study groups consisted of 32 institutionalized and 25 noninstitutionalized Brazilian elderly subjects.
Oxidative damage, inflammation markers, and cognitive function were evaluated.
The results demonstrated pronounced oxidative stress
in the institutionalized elderly group, which also had a
lower antioxidant status compared to noninstitutionalized
subjects.
• High levels of proinflammatory cytokines were also observed
in the institutionalized elderly. Furthermore, the raised levels of inflammatory markers
•
Results.
were correlated with increased oxidative stress, and both were associated with low cognitive performance.
However, based on multiple linear regression analysis, oxidative stress appears to be the main factor responsible
for the cognitive decline.
The findings suggest that individuals with lower
antioxidant status are more vulnerable to oxidative stress,
which is associated with cognitive function, leading to
reduced life quality and expectancy.
•
Conclusions.
•
http://www.ncbi.nlm.nih.gov/pubmed/25874023
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Oxidative Stress Balance goes off as we
age
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Free radicals
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
History of C-60
• C-60 discovered in 1985 by Kroto et al.
•
[Kroto, H. W.; Heath, J. P.; O'Brien, S. C.; Curl, R. F.; Smalley, R. E. C60: Buckminsterfullerene.
Nature 318:162–163; 1985.]
• Nobel prize in Chemistry in 1996
• Named after Buckminster Fuller, hence buckyballs
or fullerenes
• Touted as sil er ullet i
edi i e s ie tists
and doctors
• Dilemma; C-60, like other carbon allotropes is not
water soluble
C60 Water Canada / (416) 8199667 / walter.derzko@utoronto.ca
Making C-60 work
• Many scientists tried to make C-60 water soluble by adding
chemical derivatives, but the molecule became more toxic in
most cases
• Japa ese dis o ered Radi al spo ge a C60 deri ati e used
in topical cosmetics, approved for topical cosmetics but not
for internal use
• In 1994, Ukrainian scientists discover safe way to hydrate
pristine fullerenes without increasing toxicity
• Over 20 years of pre-clinical, clinical and safety studies
• Approved by the Ukrainian Ministry of Health 2010
• On the market since 2010
• https://www.academia.edu/11621073/Backgrounder_on_Car
bon_60_Hydrated_Fullerenes_V6
C60 Water Canada / (416) 8199667 / walter.derzko@utoronto.ca
C-60 is a Natural product
• Ubiquitous in nature
• Created in every lightening strike (80 Mill /min)
• Found in trace amounts in molasses, dark bread,
Sudbury meteorite crater, in soot, after burning
candles, wood and natural gas, bio char.
• Found in century old health spa in Russia, Shungite
rock
C60 Water Canada / (416) 8199667 / walter.derzko@utoronto.ca
C-60 is safe and non-toxic
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Pristine C-60 HYFNs are safe and non-toxic (supported by chromosome and
daughter chromatide studies in clinical trials in Ukraine in 2009-10)
July 2009. The cycle of work on preclinical and clinical trials o Water ith
h drated fullere e С60 is o pleted.
June 10, 2010, The cycle of research proving absence of any genotoxic properties
of C60 fullerene molecules in hydrated state is finished, the official report
published 10/06/2010 (in Russian), Kharkov, Ukraine.
Classified as a dietary supple e t i
y the Ukrai ia Mi istry of Health
November 19, 2010, Ministry of Healthcare of Ukraine approves the industrial use
of Concentrated Solution of Hydrated C60 Fullerene as an antioxidant in foods,
cosmetics, biotechnological and microbiological industries.
December 2, 2010, Ministry of Healthcare of Ukraine approves the use of the
multifunctional dietary supplement Water with hydrated fullerene C60 in diets.
Source:
http://ipacom.com/index.php?option=com_content&view=article&id=69&Itemid=
77&lang=en
C60 Water Canada / (416) 8199667 / walter.derzko@utoronto.ca
Commercial Production of C-60
C60 Water Canada / (416) 8199667 / walter.derzko@utoronto.ca
C60 and other biological systems
C60 Water Canada / (416) 8199667 / walter.derzko@utoronto.ca
Senior Diseases tied to Free Radicals which
Carbon 60 Hydrated Fullerenes can treat
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Arthritis
Fibromyalgia or Chronic Fatigue Syndrome
Cancer metastasis
Premature Aging / Increase longevity
Alzhei er’s a d other eurologi al diseases
Liver /age spots
Grey hair
Over 200 chronic human diseases
https://www.academia.edu/11621073/Backgrou
nder_on_Carbon_60_Hydrated_Fullerenes_V6
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
C60 Doubles the lifespan of lab rats
Univ. of Paris 2010
• https://www.indiegogo.com/projects/i-am-alittle-mouse-and-i-want-to-live-longer#activity
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
C60 Doubles the lifespan of lab rats
Univ. of Paris 2010
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
•
Biomaterials. 2012 Jun;33(19):4936-46. doi: 10.1016/j.biomaterials.2012.03.036. Epub 2012 Apr 10.
•
•
Baati T1, Bourasset F, Gharbi N, Njim L, Abderrabba M, Kerkeni A, Szwarc H, Moussa F.
Author information
• The prolongation of the lifespan of rats by repeated oral
administration of [60]fullerene.
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1UMR
CNRS 8612, Université Paris Sud XI, Rue J-B Clément-F92296, Châtenay-Malabry, France.
Erratum in
Biomaterials. 2012 Sep;33(26):6292-4.
Abstract
Countless studies showed that [60]fullerene (C(60)) and derivatives could have many potential biomedical applications. However, while several independent
research groups showed that C(60) has no acute or sub-acute toxicity in various experimental models, more than 25 years after its discovery the in vivo fate and
the chronic effects of this fullerene remain unknown. If the potential of C(60) and derivatives in the biomedical field have to be fulfilled these issues must be
Here we show that oral administration of C(60) dissolved in olive
oil (0.8 mg/ml) at reiterated doses (1.7 mg/kg of body weight) to rats
not only does not entail chronic toxicity but it almost doubles their
lifespan. The effects of C(60)-olive oil solutions in an experimental model of CCl(4) intoxication in rat strongly suggest that the effect on lifespan is
addressed.
mainly due to the attenuation of age-associated increases in oxidative stress. Pharmacokinetic studies show that dissolved C(60) is absorbed by the gastrointestinal tract and eliminated in a few tens of hours. These results of importance in the fields of medicine and toxicology should open the way for the many
including cancer therapy,
neurodegenerative disorders, and ageing.
possible -and waited for- biomedical applications of C(60)
•
Copyright © 2012 Elsevier Ltd. All rights reserved.
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Lifespan extension study update from Kyiv
• Would combinations of longevity drugs actually lengthen lifespan? NO
! NOT TRUE
• a) 23 months old C57BL6 mice received a mixture of 6 therapies that had
already been reported to extend the lifespan of mice
• 1. Aspirin
2. Everolimus (mTOR inhibitor, similar action as rapamycin)
3. Metoprol (beta blocker)
4. Metformin (anti-diabetic drug)
5. Simvastatin (lowers LDL cholesterol)
6. Ramipril (ACE inhibitor)
• The drugs were given in the food, at doses that had been reported to
extend lifespan when taken individually.
• Some people are given that combination of medicines so we hoped that the
drug interaction would not be too damaging, and we had wondered if some
lifespan synergy within some of these drugs could lead to an overall high
lifespan (eg if the different drugs improve different functions).
• But we observed a lifespan reduction in males and in females.
• https://www.indiegogo.com/projects/i-am-a-little-mouse-and-i-want-tolive-longer#activity
•
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Medical Myths-It’s all Ge eti s
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Medical Myths-It’s all Ge eti s
• Noble laureate James Watson who co-discovered
the structure of DNA visited the Salk Institute in
La Jolla and gave a lecture on oxidants and
antioxidants in cancer and diabetes.
• James Watson, who earned the Nobel Prize for
helping figure out the structure of DNA, said that
sequencing genes isn't proving to be particularly
useful in fighting such diseases as cancer and that
much of the research being done on the subject
is irrelevant.
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Medical Myths-It’s all ge eti s
• While noting that genetics is vital, Watson
said, "You could sequence 150,000 people
with cancer and its not going to cure anyone.
It might give you a few leads, but it's not, to
me, the solution. The solution is good
chemistry….(a tio ida ts and oxidants) And
that's what's lacking. We have a world of
cancer biology trained to think genes. They
don't think chemistry at all."
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Medical Myths-It’s all Ge eti s
• Watson, who had his entire genome
sequenced, said the current level of cancer
research funding is enough to find a cure. But
he added that "most of the experiments we
do are irrelevant ... We're not going to cure
cancer by doubling the money. We're going to
do it by being more intelligent. The money
thing is just a red herring of people not
thinking."
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Cancer and C60 HYFNs
• Ukrainians knew 15 years ago that C60 HYFNs could be used to cure
cancer, but there are no random double blind clinical studies to support
this claim.
• Israeli Doctors now use C60 hydrated fullerenes to treat abdominal
cancer (Treatment of cancer of the abdominal cavity ... New
technologies 4/8/2013, 23:00 Author: Solomon Ki )
• $50,000 plus for the operation; $40 USD per bottle
• http://stop-news.com/2596-lechenie-raka-organov-bryushnoy-polostinovye-tehnologii.html
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
C60 and Cancer
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Drugs R D. Dec 2014; 14(4): 333–340.
Published online Dec 12, 2014. doi: 10.1007/s40268-014-0074-4
PMCID: PMC4269825
C60 Fullerene as Synergistic Agent in Tumor-Inhibitory Doxorubicin
Treatment
Svitlana Prylutska, Iryna Grynyuk, Olga Matyshevska, Yuriy Prylutskyy,
Maxim Evstigneev, Peter Scharff, and Uwe Ritter
Joint Ukrainian-German Center on Nanobiotechnology, Kyiv, Ukraine
Taras Shevchenko National University of Kyiv, Volodymyrska Str., 64, Kyiv,
01601 Ukraine
Department of Biology and Chemistry, Belgorod State University, 85
Pobedy Str., Belgorod, 308015 Russia
Institute of Chemistry and Biotechnology, Technical University of Ilmenau,
Weimarer Str. 25, Ilmenau, 098693 Germany
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
:
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C60 and Doxorubicin
•
Abstract
Doxorubicin (Dox) is one of the most potent anticancer drugs, but its successful use is hampered by high toxicity
caused mainly by generation of reactive oxygen species. One approach to protect against Dox-dependent chemical
insult is combined use of the cytostatic drug with antioxidants. C 60 fullerene has a nanostructure with both
antioxidant and antitumor potential and may be useful in modulating cell responses to Dox.
Objective
The aim of this study was to estimate the antitumor effect and antioxidant enzyme activity of combined C 60
fullerene and Dox (C60 + Dox) in the liver and heart of mice with Lewis lung carcinoma compared with Dox
treatment alone.
Methods
Highly stable pristine C60 fullerene aqueous colloid solution (concentration 1.0 mg/ml, average hydrodynamic
diameter of nanoparticles 50 nm) was used in the study and characterized by means of atomic force microscopy
(AFM). The in vivo investigation of C60-Dox action was performed via the standard methods of histological and
enzyme activity analyses.
Results
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glutathione peroxidase inhibition induced by Dox-dependent oxidative insult in the liver and heart.
Conclusion
Combined treatment with C60 + Dox is considered to be a promising approach for cancer chemotherapy.
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• Dox (total dose 2.5 mg/kg) combined with C60 fullerene (total
dose 25 mg/kg) in tumor-bearing animals resulted in tumor
growth inhibition, prolongation of life, metastasis inhibition,
and increased number of apoptotic tumor cells and was
more effective than the corresponding course of Dox
treatment alone. C fullerene demonstrated a protective effect against superoxide dismutase and
60
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Oxidative Stress and Nursing Homes
•
•
•
•
Abstract
Objective.
Cognitive impairment reduces quality of life and is related to vascular and neurodegenerative disorders. However,
there is also a close relationship between these diseases and oxidative stress. Thus, the purpose of this study was
to assess whether inflammation and oxidative damage are associated with low cognitive performance in the
elderly with different housing conditions.
Methods. The study groups consisted of 32 institutionalized and 25 noninstitutionalized Brazilian elderly subjects.
Oxidative damage, inflammation markers, and cognitive function were evaluated.
The results demonstrated pronounced oxidative stress
in the institutionalized elderly group, which also had a
lower antioxidant status compared to noninstitutionalized
subjects.
• High levels of proinflammatory cytokines were also observed
in the institutionalized elderly. Furthermore, the raised levels of inflammatory markers
•
Results.
were correlated with increased oxidative stress, and both were associated with low cognitive performance.
However, based on multiple linear regression analysis, oxidative stress appears to be the main factor responsible
for the cognitive decline.
•
The findings suggest that individuals with lower
antioxidant status are more vulnerable to oxidative stress,
which is associated with cognitive function, leading to
reduced life quality and expectancy.
•
http://www.ncbi.nlm.nih.gov/pubmed/25874023
Conclusions.
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
How do I know if my Free Radical Level
is too high? D-I-Y test
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
ORAC Value of Foods
Food
ORAC Value per serving
Vitamin e Trilox as baseline /reference
0
Green Tea Brewed
1.128
Strawberry / Raspberry
5,938/ 6,058
Red Delicious Apple
5,900
Red Wine + carbon 60 hydrated fullerenes
8,700
Red Wine
4-5,000
Pecan
17, 940
Wild Blueberries
13, 427
Peppermint
13, 978
Cinnamon
267,538
Carbon 60 Hydrated Fullerenes Water
No ORAC value but 1,250,000
more effective than Vit E as
catalytic universal antioxidant.
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
If my Free Radicals are high, what do I
do?
• Eat antioxidant foods 3 x per day (at least
100,000 ORAC points)
• Drink C60 hydrated fullerene water monthly, (21
days) every 3 months for prophylactic treatment
• If free radicals are high, Drink C60 hydrated
fullerene water, 21 day course and repeat for 2
months depending on free radical levels in your
body to treat inflammation that is causing
disease.
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Common cause?
• Is there a common denominator between all
these new, individual 21st century diseases?
• Cancer? Heart Disease? Alzhei er’s, Parki so ’s?
Diabetes?
• YES two underlying causes
• Reduce Free radicals or oxidative stress
• Lack of essential minerals or lack
of trace minerals
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Mineral Sources
• Minerals are elements that originate in the Earth
• They cannot be made by living organisms.
• Plants obtain minerals from the soil, and most of
the minerals in our diets come directly from
plants or indirectly from animal sources.
• Minerals may also be present in the water we
drink, but this varies with geographic locale.
• Minerals from plant sources may also vary from
place to place, because soil mineral content
varies geographically.
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Soil Mineral Depletion
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Are we getting enough minerals in our
diet?
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Dog food, rat food =40 essential minerals
Baby formula = only 12 essential minerals
Vegetables and fruits = heavily depleted
Why?
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Mineral Depletion in the Soil
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Common
Minerals
(К льці )
• Cal iu
• Chro iu ( о )
• Copper (Мідь)
• нluoride ( то )
• Iodi e (Йод)
• Iro (Желі о)
• Mag esiu (М г і )
• Ma ga ese (М г ець)
• Mol de u (Молі де )
• Phosphorus ( о фо )
• Potassiu (К лі )
• “ele iu (Селе )
• Sodium (Chloride) Натрі (хлор д) Сіль
• Zi (
к)
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
But, But Salt is no good for me
Sodium
Deficiency Symptoms
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* abdominal cramps
* anorexia
* ataxia
* confusion
* crying jags
* depression
* dermatosis
* dizziness
* fatigue
* flatulence
* hallucinations
* headaches
* hypotension
* illusions
* infections
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* muscular weakness
* nausea & vomiting
* seizures
* taste loss
* weight loss
* hallucinations
* headaches
* hypotension
* illusions
* infections
* lethargy
* memory loss
* muscular weakness
* nausea & vomiting
* seizures
* taste loss
* weight loss
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Why is the soil depleted of
essential minerals?
• Electrification last century eliminated wood for heating
and cooking
• After 1880s No more wood ash that used to be thrown
in gardens and fields, no substitution
• Wood ash is 95% minerals that trees sequester from
the soil, rest is carbon and carbon 60 (bio char)
• Fertilizer only has 3 minerals. Nitrogen, Phosphorus,
Potassium, (NPK)
• Dams dammed up rivers for Rural electricity that it no
lo ger flooded far er’s fields, hi h ri gs silt
(minerals) for crops.
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Mineral Depletion
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Soil Mineral Depletion
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Consequences of Mineral Soil Depletion?
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Medical Myths-Cholesterol Bad
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Mineral Deficiencies
Senate Document No. 264, 1936.
• Mineral Deficiencies Senate Document No. 264, 1936. These are Verbatim
Unabridged extracts from the 74th Congress 2nd Session 1936
• "Our physical well-being is more directly dependent upon minerals we
take into our systems than upon calories or vitamins, or upon precise
proportions of starch, protein or carbohydrates we consume."
• "Do you know that most of us today are suffering from certain dangerous
diet deficiencies which cannot be remedied until depleted soils from
which our food comes are brought into proper mineral balance?"
• "The alarming fact is that foods (fruits, vegetables and grains) now being
raised on millions of acres of land that no longer contain enough of certain
minerals are starving us - no matter how much of them we eat. No man of
today can eat enough fruits and vegetables to supply his system with the
minerals he requires for perfect health because his stomach isn't big
enough to hold them."
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
All animals and humans require:
90 essential nutrients
• 60 essential minerals
• 15 essential vitamins
• 12 essential amino acids
• 3 essential fatty acids
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
60 Essential Minerals
(as co-factors for enzymes, proteins,
DNA, RNA)
• Calcium, Magnesium, Phosphorus, Potassium, Sodium,
Chloride, Sulfur, Cobalt, Copper, Aluminum, Arsenic,
Barium, Beryllium, Boron, Bromine, Carbon, Iodine, Iron,
Manganese, Selenium, Zinc, Cerium, Cesium, Chromium,
Dysprosium, Erbium, Europium, Gadolinium, Gallium,
Germanium, Gold, Hafnium, Holmium, Hydrogen,
Lanthanum, Lithium, Lutetium, Molybdenum, Neodymium,
Nickel, Niobium, Nitrogen, Oxygen, Praseodymium,
Rhenium, Rubidium, Samarium, Scandium, Silica, Silver,
Strontium, Tantalum, Terbium, Thulium, Tin, Titanium,
Vanadium, Ytterbium, Yttrium, Zirconium
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
How do we know that
90 nutrients is right?
Over 600 human diseases have been cured in
zoo and farm animals in the past 80 years with
proper nutrition. Why not in humans? Animals
do ’ t have OHIP. Veteri aria s eed to ure
the animal right away. Doctors treat human
symptoms not the disease and bill Health
Insurance (OHIP.)
When did you last see a cow
with arthritis or a pig with
Alzhei er’s?
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
15 Essential Vitamins
• 15 Vitamins
• Vitamin A, Vitamin B1, Vitamin B2, Vitamin
B3, Vitamin B5, Vitamin B6, Vitamin B12,
Vitamin C, Vitamin D, Vitamin K, Biotin,
Choline, Flavonoids (Bioflavonoids), Folic Acid,
Inositol
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
12 Essential Amino Acids
• 12 Amino Acids
• Valine, Lysine, Threonine, Leucine, Isoleucine,
Tryptophan, Phenylalanine, Methionine,
Histidine, Arginine, Taurine, Tyrosine
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
3 Essential Fatty Acids
• 3 Essential Fatty Acids
• Omega 3, Omega 6, Omega 9
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Blue Zones-Longest Lived people
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Why Ikaria Island and not all of Greece?
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Antioxidants of Blue Zones
Country
Antioxidants plus?
Azerbaijan
Red Wi e, Vodka, Tea, нruits, Veg’s + soil trace minerals (stm)
Sardinia,
Red Wine, Tea, Fruits, Vegetables + soil trace minerals (stm)
Nycoya, Costa Rica
Red Wine, Tea, Fruits, Vegs, Choc, Coffee + (stm)
Hunza
Red Wine, Tea, Fruits, Vegetables, + soil trace minerals (stm)
Okinawa, Japan
Rice wine, green tea, kelp, sweet potatoes, vegs + (stm)
Bama, China
Snake wine, green tea, sweet potatoes, vegs, fruits + (stm)
Vilcabamba,
Equador**
Choc, Chili pepper, Red Wine, fruits, vegs , mineral water + (stm)
Titicaca
Choc, Chili pepper, Red Wine, fruits, vegs + (stm)
Italy
Red Wine, garlic, chili pepper, fruits, veg + (stm)
Ikaria, Greece
Red Wine, fruits, vegs, garlic + (stm) + mineral springs
USA, Mormons
Berries-dark, green/yellow/red vegs, fruit + (stm)
** Longevity claims now disputed
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Sample of Calcium Deficiency Diseases
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
Arthritis
Back pains (sciatica, disc problems)
Bell's Palsy
Bone spurs
Brittle fingernails
Calcium deposits
Cognitive impairment
Delusions
Depression
Eczema
High blood pressure
Hyperactivity
Hypertension
Insomnia
Irritability
Kidney stones
Limb numbness
Muscle cramps/spasms/twitches
• Nervousness
• Neuromuscular excitability
• Osteofibrosis (enlargement of bones
with scar tissue)
• Osteomalacia (failure to mineralize
the protein bone matrix)
• Osteoporosis (& Dowaagers Hump,
spontaneous fractures, kyphosis)
• Palpitations
• Paresthesia
• Panic attacks
• Periodontal disease - receding gums
(osteoporosis of facial bones)
• PMS
• Pica (eating lead paint)
• Rickets
• Retarded growth
• Tetany
• Tooth decay
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Calcium Biochemical Pathways
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Calcium absorption barriers
• No less then 147 deficiency diseases can be
attributed to calcium deficiencies and
imbalances
• Calcium can be leached from bones, be
absorbed in blood vessels or soft tissue or
muscles vs bones, be unabsorbed by the body
or it can be excreted in the urine or lost in
sweat
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Calcium absorption barriers (20)
• Deficiency of vitamin D
• Lack of stomach acid from restricted salt
intake; too alkaline intestine
• Lactose intolerance
• Celiac disease
• High fat diet
• Low protein diet
• High fiber and phylate consumption
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Calcium absorption barriers (cont)
• Calcium + Phytic acid = calcium phytate, which
a ’t e a sor ed the od ; нou d i
grains (wheat, rye, bran, oats, rice), seeds,
stems and roots of many plants.
• Oxalic acid (rhubarb, spinach, chard, mustard
greens) forms insoluble calcium oxalate.
• Pharmaceuticals (anti-seizure drugs, diuretics)
• Excess sugar
• Gut hypermobility from too much fiber/fruits
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Calcium absorption barriers (cont)
•
•
•
•
Lack of magnesium (as magnesium citrate)
Carbonated drinks
Caffeine from coffee, tea, colas
Cortisone -- used for pain and inflammation can
contribute to severe calcium loss with prolonged use. It
also depletes potassium.
• Antacids/Acid Blockers contain aluminum hydroxide
which prevents the absorption of calcium from the
intestinal tract.
• Alcohol -- speeds up the excretion of magnesium
through the kidneys. It can also deplete, calcium, zinc,
iron, manganese, potassium and chromium.
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Disease and mineral deficiency
Alzheimer's
vitamin E
(high doses)
anemia
aortic aneurysm
arthritis
baldness
blood sugar
bone problems
bone spurs
calcium deposits
cancer
cardio myopathy
cramps, muscle
cravings
deafness
diabetes
selenium
copper
Knox gelatin
1 oz. day
tin
chromium
vanadium
selenium
calcium
(not calc. Lactate!)
calcium
(not calc. Lactate!)
Vitamin C 10,000mg/day Plus Co-factors
selenium
Miner
Vitami
ns
calcium
(not calc. Lactate!)
als
selenium
tin
chromium
vanadium
vegetable oil
calcium
(Beta Carotine)
(low doses or none)
Plus
Plus
Plus
Plus
Plus
Plus
Plus
Plus
Co-factors
Co-factors
Co-factors
Co-factors
Co-factors
Co-factors
Co-factors
Co-factors
vitamin E
Selenium
Plus
Plus
Plus
Plus
Plus
Selenium
Co-factors
Co-factors
Co-factors
Co-factors
Co-factors
bottom
Zn, Mg, Vit B1 &B3
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Disease and mineral deficiency
emotions
fainting
gingivitis
gray hair
gums, receding
heel spurs
high blood pressure
hormones
hyperactivity
hypertension
insomnia
kidney stones
learning disabilities
liver spots
longevity
longevity (cont'd)
low back pain
lumbego
menopause
Osteoporosis
palsy
PICA
PMS
rheumatism
sagging muscles
sciatica
smell loss
stroke
taste loss
boron
boron
calcium
copper
calcium
calcium
calcium
boron
chromium
calcium
calcium
calcium
selenium
selenium
(rare earths)
twitches, muscle
ulcers
varicose veins
wrinkles
Plus Co-factors
Plus Co-factors
(not calc. Lactate!)
Plus Co-factors
Plus Co-factors
(not calc. Lactate!)
(not calc. Lactate!)
(not calc. Lactate!)
Plus Co-factors
Plus Co-factors
Plus Co-factors
Plus Co-factors
vanadium
(not calc. Lactate!)
(not calc. Lactate!)
(not calc. Lactate!)
Plus Co-factors
Plus Co-factors
Plus Co-factors
magnesium
boron
Plus Co-factors
Plus Co-factors
Plus Co-factors
lanthunum
Thulium
Sumarium
calcium
calcium
boron
calcium
calcium
selenium
calcium
calcium
copper
calcium
zinc
copper
zinc
(not calc. Lactate!)
(not calc. Lactate!)
calcium
PeptoBismol
copper
copper
(not calc. Lactate!)
tetracycline
prasiodymium
europium
copper
neodymium
yiderbium
Plus Co-factors
Plus Co-factors
Plus Co-factors
Plus Co-factors
Plus Co-factors
(not calc. Lactate!)
(not calc. Lactate!)
boron
Plus Co-factors
Plus Co-factors
Plus Co-factors
(not calc. Lactate!)
(not calc. Lactate!)
Plus Co-factors
Plus Co-factors
Plus Co-factors
(not calc. Lactate!)
Plus Co-factors
Plus Co-factors
Plus Co-factors
Plus Co-factors
Plus Co-factors
Plus Co-factors
(Oramyacin)
Plus Co-factors
Plus Co-factors
Plus Co-factors
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Alzhei er’s & “upple e ts
• Curr Opin Psychiatry. 2015 Mar;28(2):141-7. doi:
10.1097/YCO.0000000000000138.
• Nutritional supplementation for Alzheimer's disease?
• Shea TB1, Remington R.
• Author information
• 1aLaboratory for Neuroscience
• bDepartment of Biological Sciences, University of
Massachusetts Lowell, Lowell, Massachusetts
• cFramingham State University, Framingham,
Massachusetts, USA.
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Alzheimer's disease & Supplements
•
•
•
Abstract
Many studies with individual vitamins or supplements show marginal, if any,
benefit.
However, new findings with combinatorial formulations demonstrate
improvement in cognitive performance and behavioral difficulties that accompany
Alzheimer's disease.
• We present novel positive effects on Alzheimer's
disease derived from diet, trace elements, vitamins
and supplements.
•
•
SUMMARY:
Overall consideration of the most recent collective evidence suggests that the
optimal approach for Alzheimer's disease would seem to combine early,
multicomponent nutritional approaches (a Mediterranean-style diet, multivitamins
and key combinatorial supplements), along with lifestyle modifications such as
social activity and mental and physical exercise, with ultimate addition of
pharmacological agents when warranted.
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Diabetes can be Reversed/Cured
• Reversal by vanadium and chromium
treatment plus essential cofactors of a
number of secondary complications relevant
to diabetes has been reported.
• The development of cataracts, common in
STZ-diabetic rats by 12 weeks after induction
of diabetes, was eliminated with vanadium
treatment
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Reversal of Type 2 Diabetes
•
•
•
•
•
•
•
R Soc Promot Health. 2002 Mar;122(1):28-34.
Oxidative stress, micronutrients, diabetes mellitus and its complications.
Opara EC1.
Author information
1Division of Experimental Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina
27710, USA. opara001@mc.duke.edu
Abstract
Oxidative stress is defined as excessive production of reactive oxygen species (ROS) in the presence of diminished
antioxidant substances. It has been shown that oxidative stress has an adverse effect on glucose metabolism.
Development of the disabling chronic complications of diabetes mellitus (DM) has also been attributed to
oxidative stress. The body's defence against oxidative stress is accomplished by interconnecting systems of
antioxidant micronutrients (vitamins and minerals) and enzymes. While the vitamins act as donors and acceptors
of ROS, minerals regulate activity of the enzymes. This review article is focused on the preventive and therapeutic
roles of these antioxidant micronutrients in DM. Although there is scarcity of data from controlled studies,
anecdotal reports indicate that the use of certain antioxidant vitamin and mineral supplements may be beneficial
as an adjunct therapy in the management of DM and its complications. In particular, it has been reported that high
doses of single micronutrient antioxidant supplements, such as vitamin E, may be beneficial to patients suffering
from this disease. However, micronutrient antioxidants interact with each other in a biochemical chain of defence
against free radicals, and the use of high doses of a single antioxidant poses potential risks because it could
perturb the antioxidant-prooxidant balance. It has, therefore, been recommended that high doses of
micronutrient antioxidant vitamins should be administered in combination rather than as single supplements.
There are a growing number of preparations containing mixtures of antioxidant vitamins and/or trace elements. A
particularly impressive supplement is a new formula called Akesis, which is a mixture of antioxidant vitamins and
antidiabetic trace elements, adequately balanced with other vitamins and minerals that enhance metabolic
processes.
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Reversal Type 2 Diabetes
•
•
•
•
See comment in PubMed Commons belowJ Investig Med. 2004 Jan;52(1):19-23.
Role of oxidative stress in the etiology of type 2 diabetes and the effect of antioxidant
supplementation on glycemic control.
Opara EC1.
Author information
1Department of Surgery, Duke University Medical Center, Durham, NC, USA.
opara001@hotmail.com
Abstract
Oxidative stress is a situation in which the amount of reactive oxygen species (ROS) exceeds the
levels of neutralizing substances referred to as antioxidants. Numerous studies have shown that
oxidative stress is associated with type 2 diabetes, and there is compelling biochemical evidence
that suggests that ROS may even play a role, if only secondary, in the pathogenesis of type 2
diabetes. These observations have provided sufficient impetus for the use of antioxidant
supplements as adjunct therapy for control of blood sugar in diabetic patients. However, there is
currently no optimum regimen of antioxidant supplementation for diabetic patients. Studies are
required to determine appropriate doses of relevant individual micronutrients that perhaps should
be used in combination to diminish oxidative stress and improve glycemic control in individuals
afflicted with type 2 diabetes.
•
BUT WE NOW KNOW THE OPTIMUM LEVEL OF MICRONUTRIENTS-90 essential nutrients
•
•
•
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Any human clinical studies?
• Have there been any human clinical studies on
the 90 nutrients?
• University of Manitoba, Richardson Center for
Functional Foods and Nutraceuticals
• Dr. Peter Jones and Dr. Ramprasath Vanu
Ramkumar
• Yй“……“afe a d йffe ti e (Positi e рealth
Effects)
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Common cause?
• Is there a common denominator between all these new,
individual 21st century diseases? Cancer? Heart Disease?
Alzhei er’s? Parki so ’s? Dia etes?
• YES two underlying causes
• Excess Free radicals or oxidative stress
• Lack of essential minerals or lack of
trace minerals
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Is it possible to live past 100? And
without chronic human diseases?
YES!!!
-Reduce Free Radicals /Oxidative Stress with C60HYFN water
-Supplement with essential minerals and trace minerals
Contact W. Derzko 416-819-9667 for information
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
Questions & Video
• Questions & Answers
• Contact Walter Derzko 416-819-9667 for
more information
Walter Derzko * (416) 819-9667 * walter.derzko@utoronto.ca
