GW Phar­ma shares dent­ed af­ter cannabi­noid drug fails a PhI­Ia study on fo­cal seizures

Af­ter round­ing up a con­sid­er­able port­fo­lio of promis­ing late-stage da­ta for its cannabis-based an­ti-con­vul­sive drug Epid­i­olex, the UK’s GW Phar­ma­ceu­ti­cals re­port­ed af­ter the mar­ket closed that an­oth­er ear­li­er-stage ther­a­py of theirs had whiffed in a Phase IIa tri­al for fo­cal seizures.

The cannabi­noid drug GWP42006 did no bet­ter than a place­bo in re­duc­ing fo­cal seizures, with com­pa­ra­ble re­duc­tions of about 40% in both arms. The drug arm did stand out in one way: outscor­ing the place­bo on ad­verse events, 73% in the drug arm com­pared to 48% in the very ac­tive place­bo arm. Most of those ad­verse events, they add, were mild to mod­er­ate.

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