How to edit a human

For decades scientists aspired to modify the code of life. Tom Whipple meets Jennifer Doudna, who succeeded

By Tom Whipple

This story begins nearly four billion years ago, when the Earth was just another rock in just another solar system. In a pool of sludge on that rock, something astonishing happened. A long stringy molecule found a way to copy itself. Similar molecules would later carry the code that would enable life forms to grow, digest, run, breathe, read, launch rockets to the Moon. But for now, that molecule only knew how to do a single, important thing – to reproduce. This was the moment that life emerged.

Since then, as each living organism has multiplied, the codes of life have altered by the tiniest increments generation after generation, stretching across time. Most of these mutations have had little impact. Very, very occasionally, they have been extraordinarily useful. The sum of millions of minuscule modifications over billions of generations has given some organisms the ability to survive in water, land, ice or the desert. They have helped them to beat disease, to be stronger, faster, fly.

More from 1843 magazine

1843 magazine | “It’s been a very long two weeks”: how the Gaza protests changed Columbia

The camp has been cleared. But the faculty of the Ivy League university remains deeply divided

1843 magazine | Rahul Gandhi is on the march. But where is he heading?

He wants to be the champion of Indian liberalism. First he needs to save his party from irrelevance


1843 magazine | It began as a rewilding experiment. Now a bear is on trial for murder

The death of a jogger in the Italian Alps has sparked a furious debate about the relationship between humans and nature