Taking Charge of All Things Autoimmune

© 2017 - All rights reserved.
Bonnie Feldman DDS MBA
Y-Dan Bui
Take Charge of All Things
Autoimmune

Take Charge of All Things Autoimmune
+1.310.666.5312
drbonnie360@gmail.com
www.drbonnie360.com
@DrBonnie360
www.facebook.com/YourAutoImmunityConnection
Bonnie Feldman, DDS, MBA
DrBonnie360’s mission is to create a digitally
connected world of personalized care for
autoimmune patients.
We consult with startup companies and
entrepreneurs who are bringing new products
and services that will improve research,
diagnosis, and treatment for autoimmunity.
Y-Dan Bui
Content and Visual Design
UCLA Class of 2016
BS, Biology

Table of Contents
Latest Findings …............................................................................................................
The Invisible Epidemic: Incidence and Prevalence ….......................................................
The Invisible Epidemic: Statistical Invisibility…...............................................................
Polyautoimmunity: No Longer Organ Specific…..............................................................
Data as an Enabling Tool: Getting Closer to Precision Medicine
Big Data: Top-Down Bottom-Up Convergence…..............................................................
Basic Science Foundation For Discovery
Immunology
New Discovery Fuels Collaboration: Immunology & Repertoire Sequencing …................
Omics
Predictive Modeling….....................................................................................................
Systems Biology and Personal Data ….............................................................................
Autoimmunity: Sorting Through the Multiple Causes
Genetics and Autoimmunity
The Genes You Can’t Take Off: What is the Relationship Between Autoimmunity ….......
and Genetics?
Causes of Autoimmunity: Genetics & Genomics …..........................................................
Page 6
Page 10
Page 12
Page 16
Page 18
Page 23
Page 28
Page 31
Page 36
Page 38

Table of Contents
Causes of Autoimmunity: Environment …......................................................................
Causes of Autoimmunity: Hormones …..........................................................................
Causes of Autoimmunity: Pathogenesis …......................................................................
Metabolomics
Causes of Autoimmunity: Microbiome Diet …................................................................
Microbiomics
The Microbiome Lifeline ….............................................................................................
The Microbiome Lifeline: Gut as An Organ of Immunity …..............................................
The Microbiome Lifeline: Gut-Brain Axis ….....................................................................
The Microbiome Lifeline: Fixing Your Leaky Gut is Key …................................................
The Microbiome Lifeline: Health Starts in the Mouth …..................................................
Epigenetics
Change Your Fate: What Can Epigenetics do for Autoimmunity? ….................................
A Different Kind of Self Help
Personal Trial and Error: Treatments & Therapies ….......................................................
Treatments & Therapies: Fecal Microbiota Transplants …...............................................
Treatments & Therapies: Prebiotics and Probiotics …......................................................
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Page 50
Page 59
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Page 68
Page 74
Page 77
Page 81
Page 86
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Page 92
Page 94

Table of Contents
Prevention and Lifestyle Modifications: What We Can Do
Prevention and Lifestyle Modifications ….......................................................................
Prevention and Lifestyle Modifications: Food ….............................................................
Prevention and Lifestyle Modifications: Diet, Food, Nutrition ….....................................
Prevention and Lifestyle Modifications: Nutrigenomics and Autoimmunity …................
Prevention and Lifestyle Modifications: Exercise …........................................................
Prevention and Lifestyle Modifications: Meditation …....................................................
Prevention and Lifestyle Modifications: Community …...................................................
Prevention and Lifestyle Modifications: The Immune System’s Feedback Loops ….........
Prevention and Lifestyle Modifications: Mind-Body Feedback Loops …..........................
Prevention and Lifestyle Modifications: Digital Health …................................................
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Page 110

Latest Findings

Latest Findings
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Latest Findings
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The Invisible Epidemic: Incidence & Prevalence
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• Hammer, Turid, et al. "The Faroese IBD Study: Incidence of Inflammatory Bowel Diseases
Across 54 Years of Population-based Data." Journal of Crohn's and Colitis 10.8 (2016): 934-942.
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The Invisible Epidemic: Incidence & Prevalence
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The Invisible Epidemic: Statistical Invisibility
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• Kubendran, S., King, J. & DeVol, R. “Checkup Time: Chronic Disease and Wellness in America.”
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Polyautoimmunity: No Longer Organ Specific
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syndrome.” Lupus 23.12 (2014): 1273-1275.
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cus_on_antiphospholipid_syndrome
• Zippi, Maddalena. “Extraintestinal manifestations in a large series of Italian inflammatory
bowel disease patients.” World Journal of Gastroenterology 20.46 (2014): 17463-17467.
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Data as an Enabling Tool:
Getting Closer to Precision Medicine

Big Data: Top-Down Bottom-Up Convergence
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• Farh, Kyle et al. “Genetic and epigenetic fine mapping of causal autoimmune disease variants.” Nature
518.7539 (2015): 337–43.
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• Greene, Casey et al. “Understanding multicellular function and disease with human tissue-specific
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• Groza, Tudor et al. “The Human Phenotype Ontology: Semantic Unification of Common and
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antic_Unification_of_Common_and_Rare_Disease
• Ramos-Casals, Manuel et al. “Google-driven search for big data in autoimmune
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• Stanberry, Larissa et al. “Integrative Analysis of Longitudinal Metabolomics Data from a
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• Xu et al. “Comprehensive serological profiling of human populations using a synthetic human
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Basic Science Foundation for Discovery

Immunology

New Discovery Fuels Collaboration: Immunology
& Repertoire Sequencing
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• Norman, Jason et al. “Disease-Specific Alterations in the Enteric Virome in Inflammatory
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Omics

Predictive Modeling
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Predictive Modeling
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Predictive Modeling
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from genetics.” Clinical & Translational Immunology 3.5 (2014): 15.
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us_disease_new_insights_from_genetics
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Systems Biology and Personal Data
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Autoimmunity:
Sorting through the Multiple Causes

Genetics and Autoimmunity

The Genes You Can’t Take Off: What is the
Relationship Between Autoimmunity and
Genetics?
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The Genes You Can’t Take Off: What is the
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Causes of Autoimmunity: Genetics & Genomics
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genetics.” Clinical & Translational Immunology 3.5 (2014).
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• Parkes, Miles et al. “Genetic insights into common pathways and complex relationships among
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• Richardson, Bruce, and Dipak Patel. “Epigenetics in 2013: DNA methylation and miRNA—key
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Metabolomics

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The Microbiome Lifeline: Gut As An Organ of
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• Struzycka, Izabela. “The oral microbiome in dental caries.” Polish journal of microbiology /
Polskie Towarzystwo Mikrobiologów = The Polish Society of Microbiologists 63.2 (2014): 127–35.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086708
• Warinner, Christina, Camilla Speller, and Matthew Collins. “A new era in palaeomicrobiology:
prospects for ancient dental calculus as a long-term record of the human oral microbiome.”
Philosophical Transactions of the Royal Society of London B: Biological Sciences 370.1660
(2015).
http://rstb.royalsocietypublishing.org/content/370/1660/20130376

• Zarco, Vess, and Ginsburg. “The oral microbiome in health and disease and the potential impact
on personalized dental medicine.” Oral Diseases 18.2 (2012): 109–120.
http://www.researchgate.net/publication/51628583_The_oral_microbiome_in_health_and_dis
ease_and_the_potential_impact_on_personalized_dental_medicine
• Zhang, Xuan et al. “The oral and gut microbiomes are perturbed in rheumatoid arthritis and
partly normalized after treatment.” Nature Medicine (2015).
http://www.researchgate.net/publication/280036160_The_oral_and_gut_microbiomes_are_p
erturbed_in_rheumatoid_arthritis_and_partly_normalized_after_treatment

Epigenetics

Change your Fate: What can Epigenetics do for
Autoimmunity?
• Allis, C. David, and Thomas Jenuwein. "The molecular hallmarks of epigenetic control." Nature
Reviews Genetics (2016). http://agri.ckcest.cn/ass/NK002-20160822003.pdf
• Coppedè, Fabio, and Lucia Migliore. "Epigenetics of autoimmune diseases." Molecular
mechanisms and physiology of disease. Springer New York, 2014. 151-173.
http://link.springer.com/chapter/10.1007/978-1-4939-0706-9_6#page-1
• Farh, K. et al. Genetic and epigenetic fine mapping of causal autoimmune disease
variants. Nature 518, 337–43 (2015).
http://www.nature.com/nature/journal/v518/n7539/full/nature13835.html

Change your Fate: What can Epigenetics do for
Autoimmunity?
• Gupta, B. & Hawkins, D. Epigenomics of autoimmune diseases. Immunol Cell Biol
93, 271–276 (2015).
http://www.nature.com/icb/journal/v93/n3/full/icb201518a.html
• Jeffries, MA & Sawalha, AH. Autoimmune disease in the epigenetic era: how has
epigenetics changed our understanding of disease and how can we expect the
field to evolve? Expert review of clinical … (2014).
http://www.pubfacts.com/detail/25534978/Autoimmune-disease-in-the-epigene
tic-era:-how-has-epigenetics-changed-our-understanding-of-disease-a

A Different Kind of Self Help

Personal Trial and Error: Treatments & Therapies
• Bot, Adrian et al. “Target discovery for T cell therapy: next steps to advance Immunotherapies.”
Journal for Immunotherapy of Cancer (2015).
http://www.immunotherapyofcancer.org/content/pdf/s40425-015-0061-5.pdf
• Burton, Bronwen et al. “Sequential transcriptional changes dictate safe and effective antigen-
specific immunotherapy.” Nature Communications (2014).
• Chang, Christopher. “Unmet needs in the treatment of autoimmunity: From aspirin to stem
cells.” Autoimmunity Reviews 13 (2014).
http://www.researchgate.net/publication/259917083_Unmet_Needs_in_the_Treatment_of_A
utoimmunity_From_Aspirin_to_Stem_Cells

• Curatola, Gerard. “Oral Microbiome Homeostasis: The New Frontier in Oral Care Therapies.”
Symbiosis (2013):1-3.
http://www.symbiosisonlinepublishing.com/dentistry-oraldisorders-therapy/dentistry-
oraldisorders-therapy05.php
• Gertner, Jon. “What’s Lurking In Your Microbiome? Possibly, a Cure for Disease.” Fast Company
(2015).
http://www.fastcompany.com/3039891/gut-check
Print.
• Olle, Bernat. “Medicines from microbiota.” Nature Biotechnology 31.4 (2013): 309-315.
http://www.researchgate.net/publication/236128149_Medicines_from_microbiota

• Petrof et al. “Microbial ecosystems therapeutics: a new paradigm in medicine?” Beneficial
microbes 4.1 (2013): 53-65.
http://www.researchgate.net/publication/233963283_Microbial_ecosystems_therapeutics_A_
new_paradigm_in_medicine
• Sabatos-Peyton, Catherine A, Johan Verhagen, and David C Wraith. “Antigen-specific
immunotherapy of autoimmune and allergic diseases.” Current opinion in immunology 22.5
(2010): 609–15.
http://www.researchgate.net/publication/46305185_Antigen-
specific_immunotherapy_of_autoimmune_and_allergic_diseases
• Velasquez-Manoff, Moises. An Epidemic of Absence. New York: Scribner, 2012. Print.

Treatments & Therapies: Fecal Microbiota
Transplants
• Borody, Thomas, and Alexander Khoruts. “Fecal microbiota transplantation and emerging
applications.” Nature Reviews Gastroenterology and Hepatology 9.2 (2011): 88–96.
http://www.researchgate.net/publication/51901488_Borody_TJ_Khoruts_A.._Fecal_microbiota
_transplantation_and_emerging_applications._Nat_Rev_Gastroenterol_Hepatol_9_88-96
• Brüssow, Harald. “Microbiota and the human nature: know thyself.” Environmental
Microbiology 17.1 (2015): 10–15.
http://www.researchgate.net/publication/269727325_Microbiota_and_the_human_nature_kn
ow_thyself
• Liu, Shirong, et al. "The host shapes the gut microbiota via fecal microRNA." Cell host & microbe
19.1 (2016): 32-43. http://www.sciencedirect.com/science/article/pii/S1931312815004977

Treatments & Therapies: Fecal Microbiota
Transplants
• Petrof, Elaine, and Alexander Khoruts. “From stool transplants to next-generation microbiota
therapeutics.” Gastroenterology 146.6 (2014): 1573-1582.
• Scher, Jose et al. “Decreased Bacterial Diversity Characterizes the Altered Gut Microbiota in
Patients With Psoriatic Arthritis, Resembling Dysbiosis in Inflammatory Bowel Disease.” Arthritis
& Rheumatology 67.1 (2015): 128–139.
http://www.researchgate.net/publication/266974816_Decreased_Bacterial_Diversity_Characte
rizes_the_Altered_Gut_Microbiota_in_Patients_With_Psoriatic_Arthritis_Resembling_Dysbiosi
s_in_Inflammatory_Bowel_Disease

Treatments & Therapies: Prebiotics and Probiotics
• Bindels, Laure et al. “Towards a more comprehensive concept for prebiotics.” Nature Reviews
Gastroenterology & Hepatology (2015).
http://www.researchgate.net/publication/274319084_Towards_a_more_comprehensive_concept_f
or_prebiotics
• Derrien, Muriel, and Johan Vlieg. “Fate, activity, and impact of ingested bacteria within the human
gut microbiota.” Trends in Microbiology (2015).
http://www.researchgate.net/publication/274405159_Fate_activity_and_impact_of_ingested_bact
eria_within_the_human_gut_microbiota
• Hemarajata, P, and J Versalovic. “Effects of Probiotics on Gut Microbiota:
Mechanisms of Intestinal Immunomodulation and Neuromodulation.” Therapeutic
Advances in Gastroenterology. (2012) :
39-51.

Treatments & Therapies: Prebiotics and Probiotics
• Petschow, B et al. “Probiotics, Prebiotics, and the Host Microbiome: The Science of
Translation.” Annals of the New York Academy of Sciences (2013) : 1-17.
http://onlinelibrary.wiley.com/doi/10.1111/nyas.12303/full
• Vieira, Angélica, Mauro Teixeira, and Flaviano Martins. “The Role of Probiotics and Prebiotics
in Inducing Gut Immunity.” Frontiers in Immunology 4 (2013): 445.
http://www.researchgate.net/publication/259492313_The_Role_of_Probiotics_and_Prebioti
cs_in_Inducing_Gut_Immunity

Prevention and Lifestyle
Modifications: What We Can Do

Prevention and Lifestyle Modifications
• “Translating the Science of Wellness and Healing.” Samueli Institute. 2011.
http://www.samueliinstitute.org/File%20Library/About%20Us/SP11_lowres.pdf

Prevention and Lifestyle Modifications: Food
• Ballantyne, Sarah. The Paleo Approach. Las Vegas: Victory Belt Publishing Inc, 2013. Print.
• Charlebois, Ashley, Greg Rosenfeld, and Brian Bressler. “The Impact of Dietary Interventions on
the Symptoms of Inflammatory Bowel Disease: A Systematic Review.” Critical Reviews in Food
Science and Nutrition (2015).
http://www.researchgate.net/publication/270651195_The_Impact_of_Dietary_Interventions_
on_the_Symptoms_of_Inflammatory_Bowel_Disease_A_Systematic_Review
• Clarke, and Mullin. “A Review of Complementary and Alternative Approaches to
Immunomodulation.” Nutrition in Clinical Practice 23.1 (2008): 49–62.
<http://www.researchgate.net/publication/5647579_A_review_of_complementary_and_altern
ative_approaches_to_immunomodulation >

• Halmos, Emma, and Peter Gibson. “Dietary management of IBD—insights and advice.” Nature
Reviews Gastroenterology & Hepatology 12.3 (2015): 133–146.
http://www.researchgate.net/publication/272083767_Dietary_management_of_IBDinsights_a
nd_advice
• LeBlanc et al. “Bacteria as vitamin suppliers to their host: a gut microbiota perspective” (2013).
http://www.researchgate.net/publication/230782474_Bacteria_as_vitamin_suppliers_to_their
_host_A_gut_microbiota_perspective
• Mullin, Gerard and Kathie Swift. The Inside Tract. New York: Rodale, 2011. Print.
Print.

• Sanfilippo, Diane. Practical Paleo: a customized approach to health and a whole-foods
lifestyle. Las Vegas: Victory Belt Publishing Inc, 2012. Print.
• Subramanian, Sathish et al. “Cultivating Healthy Growth and Nutrition through the Gut
Microbiota.” Cell (2015).
<http://www.researchgate.net/publication/274259147_Cultivating_Healthy_Growth_and_Nutr
ition_through_the_Gut_Microbiota>

Prevention and Lifestyle Modifications: Diet,
Food, Nutrition
• Bonaventura, Paola, et al. "Zinc and its role in immunity and inflammation." Autoimmunity
reviews 14.4 (2015): 277-285.
https://www.researchgate.net/profile/Paola_Bonaventura/publication/268750493_Zinc_and_its_
Role_in_Immunity_and_Inflammation/links/55fff71b08aeafc8ac8bb226/Zinc-and-its-Role-in-
Immunity-and-Inflammation.pdf
• Forster, Hannah, et al. "A dietary feedback system for the delivery of consistent personalized
dietary advice in the web-based multicenter Food4Me study." Journal of Medical Internet
Research 18.6 (2016). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945818/
• Gibson, Peter R., and Susan J. Shepherd. "Evidence‐based dietary management of functional
gastrointestinal symptoms: The FODMAP approach." Journal of gastroenterology and hepatology
25.2 (2010): 252-258. http://fodmapliving.com/wp-content/uploads/2012/07/Evidence-Based-
FODMAP-approach.pdf

Prevention and Lifestyle Modifications: Diet,
Food, Nutrition
• Tilg, H, and AR Moschen. “Food, Immunity, and the
Microbiome.” Gastroenterology 148.6 (2015) : 1107-1119.
http://www.sciencedirect.com/science/article/pii/S0016508515000128.
• vel Szic, Katarzyna Szarc, et al. "From inflammaging to healthy aging by dietary lifestyle choices: is
epigenetics the key to personalized nutrition?." Clinical epigenetics 7.1 (2015): 33.
https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-015-0068-2
• Zeevi et al. “Personalized Nutrition by Prediction of Glycemic Responses.” Cell.
163.5 (2015) : 1079-1094.
<http://www.cell.com/abstract/S0092-8674(15)01481-6>.
• Zmora, N et al. “Taking It Personally: Personalized Utilization of the Human
Microbiome in Health and Disease.” Cell Host & Microbe 19.1 (2016) : 12-20.
<http://www.cell.com/cell-host-microbe/pdf/S1931-3128(15)00508-9.pdf>.

Prevention and Lifestyle Modifications:
Nutrigenomics and Autoimmunity
• Ferguson, LR. Nutrigenetics, nutrigenomics and inflammatory bowel diseases. Expert review
of clinical immunology (2013).
• Gibson, PR, Varney, J, Malakar, S & Muir, JG. Food Components and Irritable Bowel
Syndrome. Gastroenterology (2015). at
• Minich, D. M. & Bland, J. S. Personalized lifestyle medicine: relevance for nutrition and
lifestyle recommendations. The Scientific World Journal 2013, (2013).
• Xie, G, Li, X, Li, H & Jia, W. Toward personalized nutrition: comprehensive phytoprofiling
and metabotyping. Journal of proteome research (2013).
http://pubs.acs.org/doi/abs/10.1021/pr301222b

Prevention and Lifestyle Modifications: Exercise
• Brourman, Sherry, and Randy Rodman. Walk Yourself Well. www.SherryBrourman.com. 2005.
Print.
• McCaffrey, R., and J. Park. "The benefits of yoga for musculoskeletal disorders: A systematic
review of the literature." J Yoga Phys Ther 2.122 (2012): 2.http://www.omicsgroup.info/the-
benefits-of-yoga-for-musculoskeletal-disorders-a-systematic-review-of-the-literature-2157-
7595.1000122.pdf

Prevention and Lifestyle Modifications: Meditation
Print.

Prevention and Lifestyle Modifications: Community
• Kok, BE et al. “How Positive Emotions Build Physical Health Perceived Positive Social
Connections Account for the Upward Spiral between Positive Emotions and Vagal
Tone.” Psychological Science 24.7 (2013):
1123-1132.
<http://pss.sagepub.com/content/24/7/1123.short>.

Prevention and Lifestyle Modifications: The Immune
System’s Feedback Loops
• Antoni, MH et al. “Cognitive-Behavioral Stress Management Reverses Anxiety-Related
Leukocyte Transcriptional Dynamics.” Biological Psychiatry 71.4 (2012):
366-372.
<http://www.sciencedirect.com/science/article/pii/S0006322311009656>.
• Irwin, MR, and SW Cole. “Reciprocal Regulation of the Neural and Innate Immune
Systems.” Nature Reviews Immunology 11.1 (2011) :
625-632.
http://www.nature.com/nri/journal/v11/n9/abs/nri3042.html.
• Qu, S et al. “Rapid Gene Expression Changes in Peripheral Blood Lymphocytes upon Practice of
a Comprehensive Yoga Program.” PloS One 8.4 (2013) : n. pag. .
<http://dx.plos.org/10.1371/journal.pone.0061910>.

Prevention and Lifestyle Modifications: Mind-Body
Feedback Loops
• Black, DS, and GM Slavich. “Mindfulness Meditation and the Immune System: A Systematic
Review of Randomized Controlled Trials.” Annals of the New York Academy of Sciences
20.1(2016): 1-12.
<http://onlinelibrary.wiley.com/doi/10.1111/nyas.12998/full>.
• Hill, PL, M Allemand, and BW Roberts. “Examining the Pathways between Gratitude and
Self-Rated Physical Health across Adulthood.” Personality and Individual Differences 54.1
(2013): 92-96.
<http://www.sciencedirect.com/science/article/pii/S0191886912004011>.
• Neff, KD, and CK Germer. “A Pilot Study and Randomized Controlled Trial of the Mindful
Self‐compassion Program.” Journal of Clinical Psychology(2013): 1-17.
<http://onlinelibrary.wiley.com/doi/10.1002/jclp.21923/full>.

Prevention and Lifestyle Modifications: Mind-Body
Feedback Loops
• Tang, YY, BK Hölzel, and MI Posner. “The Neuroscience of Mindfulness Meditation.” Nature
Reviews Neuroscience 16.1 (2015):
213-225.
<http://www.nature.com/nrn/journal/v16/n4/abs/nrn3916.html>.

Prevention and Lifestyle Modifications: Digital Health
• Altshuler, David and et al. "Creating a Global Alliance to Enable Responsible Sharing of Genomic
and Clinical Data." 2013 June 3. http://genomicsandhealth.org/about-the-global-alliance/key-
documents/white-paper-creating-global-alliance-enable-responsible-shar
• Cnossen, Rick, Wendy Nilsen, et al. "White Paper: Data Collection and Mobile
Technologies." Precision Medicine Meeting (2014): 1-13 Web
http://www.nih.gov/precisionmedicine/whitepapers/Data-Collection-Mobile-Technologies.pdf
• Elenko, Eric, Lindsay Underwood, and Daphne Zohar. “Defining digital medicine.” Nature
Biotechnology (2015).
http://www.researchgate.net/publication/276208474_Defining_digital_medicine

• Gehrman, Philip, et al. "Feasibility of Group Cognitive-Behavioral Treatment of Insomnia
Delivered by Clinical Video Telehealth." Telemedicine and e-Health 22.12 (2016): 1041-1046.
http://online.liebertpub.com/doi/abs/10.1089/tmj.2016.0032
• Housman, Dan. "Marketing Research: Collaboration Proclamation." Medical Marketing &
Media (2015): 36- 37. Web. http://www.mmm-online.com/features/marketing-research-
collaboration-proclamation/article/400196/
• Maecker, Holden, Tamsin M. Lindstrom, and et al. "New Tools for Classification and Monitoring
of Autoimmune Diseases." Nature Reviews Rheumatology. 8.1 (2012): 317-328. Web
http://www.researchgate.net/publication/225078353_New_tools_for_classification_and_moni
toring_of_autoimmune_diseases

• Mandl, Kenneth D., Joshua C. Mandel, and Isaac S. Kohane. "Driving innovation in health
systems through an apps-based information economy." Cell systems 1.1 (2015): 8-13.
http://www.cell.com/cell-systems/fulltext/S2405-4712(15)00004-6
• Margolis, Peter, Laura Peterson, and Michael Seid. “Collaborative Chronic Care Networks
(C3Ns) to transform chronic illness care.” Pediatrics 131.Supplement 4 (2013): S219–S223.
http://www.researchgate.net/publication/269912722_Collaborative_Chronic_Care_Networks_
(C3Ns)_to_Transform_Chronic_Illness_Care
• Milani, Richard, and Carl Lavie. “Health care 2020: reengineering health care delivery to combat
chronic disease.” The American journal of medicine 128.4 (2014): 337–43.
http://www.researchgate.net/publication/268692852_Health_Care_2020_Reengineering_Heal
th_Care_Delivery_to_Combat_Chronic_Disease

• Spanakis, Emmanouil G., et al. "Technology-Based Innovations to Foster Personalized Healthy
Lifestyles and Well-Being: A Targeted Review." Journal of Medical Internet Research 18.6
(2016). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938884/
• Topol, Eric. The Patient Will See You Now. New York: Basic Books, 2015. Print.

Take Charge of All Things
Autoimmune
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Business Development for Digital Health

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