grandiflorus at concentrations of 25, 50 and 80 [micro]g / mL of culture medium, there were no differences in the number of
binucleate cells with micronucleus between treatments with different doses of phytoterapic and the negative control (Fig.
(d) Granular immunoreactivity for Synaptophysin highlights dysplastic neurons, some of which are
binucleate (arrows).
In some of the specimens, regenerative changes such as anisocytosis and presence of
binucleate cells were also noted in the experimental animals.
The glycosylation of pregnancy-associated glycoproteins and prolactin-related protein-I in bovine
binucleate trophoblast giant cells changes before parturition.
Micronuclei, which are the primary cytological structures scored in the CBMN assay, are thought to contain chromatin (from one or more chromosomes) that was not incorporated ("lagging" or "lost") into the daughter
binucleates following nuclear division [34].
There were scattered apoptotic cells, few
binucleate cells, and multifocal areas of necrosis within the mass.
A microscopical study of uterine lining modification,
binucleate cell numbers and trophoblastic development, at 14, 20 and 24 of day gestation in single and multiple pregnancies in sheep.
CBPI was calculated as (number mononucleate cells + 2x number
binucleate cells + 3x number poiynucleate cells) + total number of cells.
Morphine sulfate ([10.sup.-4] M) alone had no effect on the observed frequency of micronucleated
binucleate cells, whereas mitomycin C (1.5 x [10.sup.-7] M) increased the frequency approximately 9-fold (Table 1).
(28) The
binucleate: mononucleate cell ratio may therefore prove to be an important biomarker for identifying individuals with a cytokinesis failure caused by higher-than-normal rates of aneuploidy, such as that observed in Down's syndrome.
Although much of the surface area of these placentas fits the epitheliochorial structure, large
binucleate cells from the trophectoderm migrate into the underlying endometrial epithelium and establish direct contact with the basement membrane.