*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : IO2100000
CHEMICAL NAME : 1,4:5,8-Dimethanonaphthalene,
1,2,3,4,10,10-hexachloro-1,4,4a,5,8,8a-hexahydro-,
endo,exo-
CAS REGISTRY NUMBER : 309-00-2
OTHER CAS REGISTRY NOS. : 34487-55-3
LAST UPDATED : 199712
DATA ITEMS CITED : 112
MOLECULAR FORMULA : C12-H8-Cl6
MOLECULAR WEIGHT : 364.90
WISWESSER LINE NOTATION : L D5 C55 A D- EU JUTJ AG AG BG IG JG KG ENDO EXO
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Aldrex
* Aldrex 30
* Aldrex 30 E.C.
* Aldrin
* Aldrine
* Aldrite
* Aldrosol
* Altox
* Compound 118
* ENT 15,949
* Hexachlorohexahydro-endo-exo-dimethanonaphthalene
* 1,2,3,4,10,10-Hexachloro-1,4,4a,5,8,8a-hexahydro-1,4,5,8-dimethanonaphth
alene
* 1,2,3,4,10,10-Hexachloro-1,4,4a,5,8,8a-hexahydro-exo-1,4-endo-5,8-dimeth
anonaphthalene
* 1,2,3,4,10,10-Hexachloro-1,4,4a,5,8,8a-hexahydro-1,4-endo-exo-5,8-dimeth
anonaphthalene
* HHDN
* Kortofin
* Latka 118
* NCI-C00044
* Octalene
* RCRA waste number P004
* SD 2794
* Seedrin
* Tatuzinho
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 14 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - excitement
Gastrointestinal - nausea or vomiting
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,82,1969
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - child
DOSE/DURATION : 1250 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,82,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 39 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SPEADM Special Publication of the Entomological Society of America. (4603
Calvert Rd., College Park, MD 20740) Volume(issue)/page/year: 78-1,12,1978
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5800 ug/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,73,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 98 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
14,515,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
11,302,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 62 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,73,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 44 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SPEADM Special Publication of the Entomological Society of America. (4603
Calvert Rd., College Park, MD 20740) Volume(issue)/page/year: 78-1,12,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp.,
233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year:
2,80,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 21 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
32ZDAL "Aldrin Dieldrin Endrin and Telodrin: An Epidemiological and
Toxicological Study of Long-Term Occupational Exposure," Jager, K.W., New
York, Elsevier Science Pub. Co., 1970 Volume(issue)/page/year: -,52,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intracerebral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 60,289,1992
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 65 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,7,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 1999 mg/kg
TOXIC EFFECTS :
Liver - liver function tests impaired
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
10,119,1967
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 95 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 3,64,1951
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 15 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - other changes
REFERENCE :
CVETAA Communicationes Veterinariae. (Bogor, Indonesia) V.1-9, 1957-65.
Discontinued. Volume(issue)/page/year: 2,71,1958
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 75 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - other changes
REFERENCE :
CVETAA Communicationes Veterinariae. (Bogor, Indonesia) V.1-9, 1957-65.
Discontinued. Volume(issue)/page/year: 2,71,1958
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,7,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 15 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
JEENAI Journal of Economic Entomology. (Entomological Soc. of America, 4603
Calvert Rd., College Park, MD 20740) V.1- 1908- Volume(issue)/page/year:
46,702,1953
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,73,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 33 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,7,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 9,11,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - pigeon
DOSE/DURATION : 56200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing
Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
Volume(issue)/page/year: (680),157,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Behavioral - changes in motor activity (specific assay)
REFERENCE :
JEENAI Journal of Economic Entomology. (Entomological Soc. of America, 4603
Calvert Rd., College Park, MD 20740) V.1- 1908- Volume(issue)/page/year:
45,121,1952
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - quail
DOSE/DURATION : 42100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing
Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
Volume(issue)/page/year: (680),157,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - duck
DOSE/DURATION : 520 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept.,
Midland, MI 48640) V.1- 1945- Volume(issue)/page/year: 35,25,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag
New York, Inc., 1971 Volume(issue)/page/year: -,62,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - wild bird species
DOSE/DURATION : 7200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
21,315,1972
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 9100 ug/kg/26W-I
TOXIC EFFECTS :
Endocrine - other changes
Blood - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 31(4),13,1966
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 109 mg/kg/2Y-C
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.1- 1953- Volume(issue)/page/year: 3,402,1955
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 348 mg/kg/58D-C
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other esterases
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 9,306,1954
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 290 mg/kg/58D-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other esterases
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 9,306,1954
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 81120 ug/kg/68W-I
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.1- 1953- Volume(issue)/page/year: 3,402,1955
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 91500 ug/kg/61D-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory
change
Behavioral - convulsions or effect on seizure threshold
Related to Chronic Data - death
REFERENCE :
CVETAA Communicationes Veterinariae. (Bogor, Indonesia) V.1-9, 1957-65.
Discontinued. Volume(issue)/page/year: 2,71,1958
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 200 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 2,551,1964
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 270 mg/kg/80W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-21,1978
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 540 mg/kg/80W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-21,1978
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 188 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - multiple effects
Lungs, Thorax, or Respiration - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
11,88,1967
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 1950 ug/kg
SEX/DURATION : male 13 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
Endocrine - androgenic
REFERENCE :
ANDRDQ Andrologia. (Grosse Verlag GmbH, Kurfuerstenstr. 112-113, D-1000
Berlin 30, Fed. Rep. Ger.) V.6- 1974- Volume(issue)/page/year:
20,472,1988
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 3900 ug/kg
SEX/DURATION : male 26 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
REFERENCE :
ANDRDQ Andrologia. (Grosse Verlag GmbH, Kurfuerstenstr. 112-113, D-1000
Berlin 30, Fed. Rep. Ger.) V.6- 1974- Volume(issue)/page/year:
20,472,1988
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 10 mg/kg
SEX/DURATION : female 2 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 16,131,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 22 mg/kg
SEX/DURATION : female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao
Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao
Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981-
Volume(issue)/page/year: 22,979,1989
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 21 mg/kg
SEX/DURATION : lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
Reproductive - Effects on Newborn - behavioral
REFERENCE :
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao
Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao
Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981-
Volume(issue)/page/year: 22,979,1989
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 25 mg/kg
SEX/DURATION : female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 9,11,1974
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE : 73 mg/kg
SEX/DURATION : female 44 week(s) pre-mating
female 1-8 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
JAVMA4 Journal of the American Veterinary Medical Association. (American
Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48-
1915- Volume(issue)/page/year: 123,28,1953
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - hamster
DOSE : 50 mg/kg
SEX/DURATION : female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 9,11,1974
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - hamster
DOSE : 50 mg/kg
SEX/DURATION : female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 9,11,1974
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 5 ppm
REFERENCE :
RSTUDV Rivista di Scienza e Technologia degli Alimenti e di Nutrizione
Umana. Review of Science and Technology of Food and Human Nutrition.
(Bologna, Italy) V.5-6, 1975-76. Discontinued. Volume(issue)/page/year:
6,161,1976
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 42,161,1977
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 100 mg/L
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
45,101,1980
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 19125 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 31,103,1975
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Leukocyte
DOSE/DURATION : 19125 ug/L
REFERENCE :
PHTHDT Pharmacology and Therapeutics. (Pergamon Press Ltd., Headington Hill
Hall, Oxford OX3 0BW, UK) V.4- 1979- Volume(issue)/page/year:
6,147,1979
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 300 umol/L
REFERENCE :
SinJF# Personal Communication from J.F. Sina, Merck Institute for
Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
Volume(issue)/page/year: 26OCT1982
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 100 mg/L
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
45,101,1980
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 9560 ug/kg
REFERENCE :
PHTHDT Pharmacology and Therapeutics. (Pergamon Press Ltd., Headington Hill
Hall, Oxford OX3 0BW, UK) V.4- 1979- Volume(issue)/page/year:
6,147,1979
TYPE OF TEST : Unscheduled DNA synthesis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 11 umol/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 8,1433,1987
TYPE OF TEST : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 10 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 343,157,1995
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 9560 ug/kg
REFERENCE :
PHTHDT Pharmacology and Therapeutics. (Pergamon Press Ltd., Headington Hill
Hall, Oxford OX3 0BW, UK) V.4- 1979- Volume(issue)/page/year:
6,147,1979
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 13 mg/kg
REFERENCE :
IMSCE2 IRCS Medical Science. (Lancaster, UK) V.12-14, 1984-86. For
publisher information, see MSCREJ. Volume(issue)/page/year: 14,1125,1986
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Fish - not otherwise specified
DOSE/DURATION : 3000 ppm
REFERENCE :
NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in
Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta
700 019, India) V.1- 1958- Volume(issue)/page/year: 28,176,1985
*** REVIEWS ***
ACGIH TLV-Animal carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.25 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Limited Evidence
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,88,1987
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 5,25,1974
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,88,1987
TOXICOLOGY REVIEW
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 7,243,1974
TOXICOLOGY REVIEW
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year:
48,141,1973
TOXICOLOGY REVIEW
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year:
56,107,1975
TOXICOLOGY REVIEW
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.)
V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973
TOXICOLOGY REVIEW
BNYMAM Bulletin of the New York Academy of Medicine. (New York Academy of
Medicine, 2 E. 103rd St., New York, NY 10029) Ser 2: V.1- 1925-
Volume(issue)/page/year: 54,413,1978
TOXICOLOGY REVIEW
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer
Congress," Chicago, Year Book Medical Pub., 1971 Volume(issue)/page/year:
5,250,1970
TOXICOLOGY REVIEW
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher
information, see JTCTDW. Volume(issue)/page/year: 13,231,1978
TOXICOLOGY REVIEW
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year:
1,89,1977
TOXICOLOGY REVIEW
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
10,613,1967
TOXICOLOGY REVIEW
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB82-219007
TOXICOLOGY REVIEW
26UZAB "Pesticides Symposia; Collection of Papers Presented at the Sixth &
Seventh Inter-American Conferences on Toxicology and Occupational Medicine,
Miami, FL," Miami, FL, J.L. Halos, 1968-70 Volume(issue)/page/year:
6,149,1968/1970
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 0.25 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,7,1971
OSHA PEL (Gen Indu):8H TWA 0.25 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.25 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.25 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.25 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt;Skin JAN 1993
OEL-AUSTRALIA:TWA 0.25 mg/m3;Skin JAN 1993
OEL-BELGIUM:TWA 0.25 mg/m3;Skin JAN 1993
OEL-DENMARK:TWA 0.25 mg/m3;Skin JAN 1993
OEL-FINLAND:TWA 0.25 mg/m3;STEL 0.75 mg/m3;Skin JAN 1993
OEL-FRANCE:TWA 0.25 mg/m3;Skin JAN 1993
OEL-GERMANY:TWA 0.25 mg/m3;Skin JAN 1993
OEL-INDIA:TWA 0.25 mg/m3;Skin JAN 1993
OEL-THE NETHERLANDS:TWA 0.25 mg/m3;Skin JAN 1993
OEL-THE PHILIPPINES:TWA 0.25 mg/m3;Skin JAN 1993
OEL-POLAND:TWA 0.01 mg/m3;STEL 0.08 mg/m3;Skin JAN 1993
OEL-RUSSIA:STEL 0.01 mg/m3;Skin JAN 1993
OEL-SWITZERLAND:TWA 0.25 mg/m3;Skin JAN 1993
OEL-THAILAND:TWA 0.25 mg/m3 JAN 1993
OEL-TURKEY:TWA 0.25 mg/m3;Skin JAN 1993
OEL-UNITED KINGDOM:TWA 0.25 mg/m3;STEL 0.75 mg/m3;Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO ALDRIN-air:10H CA TWA 0.25 mg/m3 (Sk) (0.15 mg/m3 LOQ)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 04260
No. of Facilities: 43 (estimated)
No. of Industries: 1
No. of Occupations: 8
No. of Employees: 605 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 04260
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 42 (estimated)
No. of Female Employees: 7 (estimated)
*** STATUS IN U.S. ***
ATSDR TOXICOLOGY PROFILE
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB/89/214514/AS
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S
cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Aldrin, 5502
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-21,78
NCI Carcinogenesis Bioassay (feed);equivocal evidence:rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-21,78
*** END OF RECORD ***
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