Inorganic-organic magnetic nanocomposites for use in preventive medicine: a rapid and reliable elimination system for cesium

Pharm Res. 2012 May;29(5):1404-18. doi: 10.1007/s11095-011-0628-x. Epub 2011 Dec 7.

Abstract

Purpose: To investigate the potential use of Prussian blue-coated magnetic nanoparticles, termed "Prussian blueberry", to bring about the magnetic elimination of cesium.

Methods: Prussian blueberry were prepared by a layer-by-layer assembly method. The morphology, structure and physical properties of the Prussian blueberry were investigated as was their ability to magnetically eliminate cesium.

Results: We confirmed that Prussian blueberry were composed of a magnetite nanoparticle-core and a Prussian blue-shell. Under a magnetic field, Prussian blueberry (5 mg) reduced the cesium concentration of seawater (3 ml) from 150 ppm to about 50 ppm; but regular Prussian blue could not magnetically eliminate cesium. Moreover, Prussian blueberry removed a similar proportion of cesium from a larger volume of seawater, and from fetal bovine serum and cow's milk.

Conclusions: Under a magnetic field, Prussian blueberry was able to rapidly eliminate cesium from seawater and from biological matrices such as serum and milk.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carcinogens, Environmental / chemistry
  • Cattle
  • Cesium / analysis
  • Cesium / blood
  • Cesium / chemistry
  • Cesium / metabolism*
  • Cesium Radioisotopes / analysis
  • Cesium Radioisotopes / blood
  • Cesium Radioisotopes / chemistry
  • Cesium Radioisotopes / metabolism
  • Drug Stability
  • Ferrocyanides / chemistry*
  • Hydrogen-Ion Concentration
  • Magnetics*
  • Milk / chemistry
  • Nanocomposites*
  • Preventive Medicine
  • Seawater / chemistry
  • Spectroscopy, Fourier Transform Infrared
  • Surface Properties
  • Time Factors
  • X-Ray Diffraction

Substances

  • Carcinogens, Environmental
  • Cesium Radioisotopes
  • Ferrocyanides
  • Cesium
  • ferric ferrocyanide