Impact of chemotherapy on cancer-related fatigue and cytokines in 1312 patients: a systematic review of quantitative studies.

Eyob T; Ng T; Chan R; Chan A

doi:10.1097/spc.0000000000000205

Impact of chemotherapy on cancer-related fatigue and cytokines in 1312 patients: a systematic review of quantitative studies.

Eyob T ¹,

Ng T ,

Chan R ,

Chan A

Affiliations

1. aDepartment of Pharmacy, National University of Singapore, Singapore bDepartment of Pharmacy, National Cancer Centre Singapore, Singapore cQueensland University of Technology, Brisbane Queensland, Australia dRoyal Brisbane and Women's Hospital, Herston, QLD, Australia eDuke-NUS Medical School Singapore, Singapore.
Authors
Eyob T¹
(1 author)

ORCIDs linked to this article

Current Opinion in Supportive and Palliative Care, 01 Jun 2016, 10(2):165-179
https://doi.org/10.1097/spc.0000000000000205 PMID: 27043288

Review

Abstract

Purpose of review

Cancer-related fatigue (CRF) is the most common psychosomatic distress experienced by cancer patients before, during and after chemotherapy. Its impact on functional status and Health Related Quality of Life is a great concern among patients, healthcare professionals and researchers. The primary objective of this systematic review is to determine whether the different chemotherapies affect the association of CRF with individual pro- and anti-inflammatory cytokines. The PRISMA statement guideline has been followed to systematically search and screen article from PubMed and Embase.

Recent findings

This review has examined 14 studies which included a total of 1312 patients. These studies assayed 20 different kinds of cytokines. The cytokines interleukin-6, interleukin-1RA, TGF-β and sTNF-R2 were associated with CRF in patients receiving anthracycline-based chemotherapy. However, only interleukin-13 was identified in the taxane-based chemotherapy. Similarly, different sets of cytokines were linked with CRF in patients with chemotherapy regimens containing platinum, cyclophosphamides, topotecan or bleomycin.

Summary

This review has identified that cytokines are differentially linked with CRF according to the various types of chemotherapy regimens.

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Articles in the Open Access Subset are available under a Creative Commons license. This means they are free to read, and that reuse is permitted under certain circumstances. There are six different Creative Commons licenses available, see the copyright license for this article to understand what type of reuse is permitted.
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Impact of chemotherapy on cancer-related fatigue and cytokines in 1312 patients: a systematic review of quantitative studies.

Affiliations

Authors

ORCIDs linked to this article

Abstract

Purpose of review

Recent findings

Summary

Full text links

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

Mitigating long-term and delayed adverse events associated with cancer treatment: implications for survivorship.

Tocilizumab overcomes chemotherapy resistance in mesenchymal stem-like breast cancer by negating autocrine IL-1A induction of IL-6.

Serum metabonomics as a diagnostic approach for cancer-related fatigue.

Exercise Training Preserves Myocardial Strain and Improves Exercise Tolerance in Doxorubicin-Induced Cardiotoxicity.

Depression, anxiety, fatigue, and quality of life in a large sample of patients suffering from head and neck cancer in comparison with the general population.

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Impact of chemotherapy on cancer-related fatigue and cytokines in 1312 patients: a systematic review of quantitative studies.

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Abstract

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Summary

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