BACITHROCINS A, B AND C, NOVEL THROMBIN INHIBITORS

TSUTOMU KAMIYAMA; TAKAYUKI UMINO; YUMIKO NAKAMURA; YOSHIKO ITEZONO; SAYOKO SAWAIRI; TOMOKO SATOH; KAZUTERU YOKOSE

doi:10.7164/antibiotics.47.959

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

BACITHROCINS A, B AND C, NOVEL THROMBIN INHIBITORS

TSUTOMU KAMIYAMA, TAKAYUKI UMINO, YUMIKO NAKAMURA, YOSHIKO ITEZONO, SAYOKO SAWAIRI, TOMOKO SATOH, KAZUTERU YOKOSE

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JOURNAL FREE ACCESS

1994 Volume 47 Issue 9 Pages 959-968

DOI https://doi.org/10.7164/antibiotics.47.959

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Abstract

Novel thrombin inhibitors, bacithrocins A, B and C, have been isolated from the culture broth of Bacillus laterosporus Laubach NR 2988. The structures of these inhibitors have been determined to be N-acyl-L-phenylalanyl-DL-arginal by the 2D-NMR experiments on their oxidation products and by amino acid analysis. Bacithrocin A inhibits thrombin, factor Xa and trypsin with IC₅₀s of 48, 13 and 0.65μM, respectively, which are similar to those of bacithrocins B and C. Bacithrocins prolong the clotting time induced by thrombin and factor Xa.

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