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An IARC Monographs Working Group of 23 experts from 13 countries convened to evaluate the evidence of carcinogenicity of drinking-water disinfectants and of arsenic (mostly naturally occurring) as a contaminant of drinking-water, and of the water-disinfectant chloramine. The Working Group also evaluated or re-evaluated four chlorination by-products found in drinking-water, namely chloral hydrate, di- and trichloroacetic acids, and 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (also known as MX).
Contents
- NOTE TO THE READER
- LIST OF PARTICIPANTS
- PREAMBLE
- GENERAL REMARKS
- THE MONOGRAPHS
- Arsenic in drinking-water
- Monographs on Chloramine, Chloral and Chloral Hydrate, Dichloroacetic Acid, Trichloroacetic Acid and 3-Chloro-4-(Dichloromethyl)-5- Hydroxy-2(5H)-Furanone
- Chloramine
- Chloral and chloral hydrate
- Dichloroacetic acid
- Trichloroacetic acid
- 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX)
- SUMMARY OF FINAL EVALUATIONS
Corrigenda to the IARC Monographs are published online at http://monographs.iarc.fr/ENG/Publications/corrigenda.php.
Corrigenda to Volume 84. (PDF, 44K)
LIBRARY CATALOGUING DATA
This publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 15–22 October 2002
Lyon, France - 2004
IARC MONOGRAPHS
In 1969, the International Agency for Research on Cancer (IARC) initiated a programme on the evaluation of the carcinogenic risk of chemicals to humans involving the production of critically evaluated monographs on individual chemicals. The programme was subsequently expanded to include evaluations of carcinogenic risks associated with exposures to complex mixtures, life-style factors and biological and physical agents, as well as those in specific occupations.
The objective of the programme is to elaborate and publish in the form of monographs critical reviews of data on carcinogenicity for agents to which humans are known to be exposed and on specific exposure situations; to evaluate these data in terms of human risk with the help of international working groups of experts in chemical carcinogenesis and related fields; and to indicate where additional research efforts are needed.
The lists of IARC evaluations are regularly updated and are available on Internet: http://monographs.iarc.fr/
This project was supported by Cooperative Agreement 5 UO1 CA33193 awarded by the United States National Cancer Institute, Department of Health and Human Services, and was funded in part by the European Commission, Directorate-General EMPL (Employment, and Social Affairs), Health, Safety and Hygiene at Work Unit. Additional support has been provided since 1993 by the United States National Institute of Environmental Health Sciences.
This publication was made possible in part by a Cooperative Agreement between the United States Environmental Protection Agency, Office of Research and Development (US EPA, ORD) and IARC and does not necessarily express the views of the US EPA, ORD.
- ©International Agency for Research on Cancer, 2004
- Distributed by IARCPress (Fax: +33 4 72 73 83 02; E-mail: rf.crai@sserp) and by the World Health Organization Marketing and Dissemination (MDI), 1211 Geneva 27 (Fax: +41 22 791 4857; E-mail: tni.ohw@snoitacilbup)
- Publications of the World Health Organization enjoy copyright protection in accordance with the provisions of Protocol 2 of the Universal Copyright Convention.
- All rights reserved. Application for rights of reproduction or translation, in part or in toto, should be made to the International Agency for Research on Cancer.
IARC Library Cataloguing in Publication Data
Some drinking-water disinfectants and contaminants, including arsenic /
- IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2004 : Lyon, France)
- (IARC monographs on the evaluation of carcinogenic risks to humans ; 84)
- 1. Carcinogens – congresses 2. Drinking-water disinfectants – congresses
- 3. Drinking-water contaminants – congresses 4. Arsenic – congresses
- I. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans II. Series
- ISBN 92 832 1284 3 (NLM Classification: W1)
- ISSN 1017-1606
- PRINTED IN FRANCE
Cover design by Georges Mollon, IARC
- NLM CatalogRelated NLM Catalog Entries
- Some drinking-water disinfectants and contaminants, including arsenic. Monographs on chloramine, chloral and chloral hydrate, dichloroacetic acid, trichloroacetic acid and 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone.[IARC Monogr Eval Carcinog Risk...]Some drinking-water disinfectants and contaminants, including arsenic. Monographs on chloramine, chloral and chloral hydrate, dichloroacetic acid, trichloroacetic acid and 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone.IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. IARC Monogr Eval Carcinog Risks Hum. 2004; 84:269-477.
- Mutagenicity of three disinfection by-products: di- and trichloroacetic acid and chloral hydrate in L5178Y/TK +/- (-)3.7.2C mouse lymphoma cells.[Mutat Res. 1998]Mutagenicity of three disinfection by-products: di- and trichloroacetic acid and chloral hydrate in L5178Y/TK +/- (-)3.7.2C mouse lymphoma cells.Harrington-Brock K, Doerr CL, Moore MM. Mutat Res. 1998 Mar 30; 413(3):265-76.
- The occurrence of disinfection by-products in municipal drinking water in China's Pearl River Delta and a multipathway cancer risk assessment.[Sci Total Environ. 2013]The occurrence of disinfection by-products in municipal drinking water in China's Pearl River Delta and a multipathway cancer risk assessment.Gan W, Guo W, Mo J, He Y, Liu Y, Liu W, Liang Y, Yang X. Sci Total Environ. 2013 Mar 1; 447:108-15. Epub 2013 Feb 1.
- Review [Significance of trihalomethanes in drinking water].[Gig Sanit. 1984]Review [Significance of trihalomethanes in drinking water].Novikov IuV, Noarov IuA. Gig Sanit. 1984 Apr; (4):51-5.
- Review Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research.[Mutat Res. 2007]Review Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research.Richardson SD, Plewa MJ, Wagner ED, Schoeny R, Demarini DM. Mutat Res. 2007 Nov-Dec; 636(1-3):178-242. Epub 2007 Sep 12.
- Some Drinking-water Disinfectants and Contaminants, including ArsenicSome Drinking-water Disinfectants and Contaminants, including Arsenic
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