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Asymmetric Centrosome Behavior in Stem Cell Divisions

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The Centrosome

Abstract

Stem cells are well known for their self-renewal ability and differentiation potential. It is critical to regulate stem cell self-renewal and differentiation, both during fast growth in development and tissue homeostasis in adulthood. One way to maintain tissue homeostasis is through asymmetric stem cell division, in which centrosomes play an important role in establishing mitotic spindles by acting as a microtubule organization center (MTOC). In this chapter, the asymmetric behavior of centrosomes during stem cell division will be discussed based on their structural, behavioral, and developmental asymmetry.

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Acknowledgment

The authors wish to acknowledge financial support from Chicago Biomedical Consortium from The Searle Funds at The Chicago Community Trust to J.C., Postdoctoral Fellowship from the Training Program in Organogenesis (T-32-HD007505) to T.M.R., and MacArthur Foundation to Y.M.Y.

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Authors and Affiliations

  1. Life Sciences Institute, Center for Stem Cell Biology, Ann Arbor, MI,  USA

    Therese M. Roth & Yukiko M. Yamashita

  2. Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA

    Therese M. Roth & Yukiko M. Yamashita

  3. Department of Bioengineering, University of Illinois, Chicago, IL, USA

    Jun Cheng

Authors
  1. Therese M. Roth
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  2. Yukiko M. Yamashita
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  3. Jun Cheng
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Corresponding author

Correspondence to Jun Cheng .

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Editors and Affiliations

  1. Dept. Veterinary Pathobiology, University of Missouri-Columbia, East Rollins Street 1600, Columbia, 65211, Missouri, USA

    Heide Schatten

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© 2012 Humana Press, a part of Springer Science+Business Media, LLC

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Roth, T.M., Yamashita, Y.M., Cheng, J. (2012). Asymmetric Centrosome Behavior in Stem Cell Divisions. In: Schatten, H. (eds) The Centrosome. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-035-9_6

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