Related Offerings
In-vitro ADME Services
In vitro facilities at PDS provide absorption, distribution, metabolism, and excretion (ADME) services for faster and improved decision making points or standalone offering to support drug discovery programs. Cost-efficient, standardized and customized assays for ADME parameters are provided to the clients.
Our ADME capabilities include:
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Physicochemical screening
- Aqueous solubility (Thermodynamic and Kinetic method)
- Log P (Octanol/water)
- Log D (Octanol/PBS)
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Permeability
- PAMPA
- CaCo – 2
- MDCK (wild type)
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Protein Binding
- Plasma Protein Binding (Equilibrium Dialysis)
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Drug Metabolism
- Hepatocyte Stability
- Microsomal Stability
- Plasma Stability
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Drug-Drug interaction
- CYP inhibition assays (Fluorescent and LCMS/MS based)
- Others
- P-Glycoprotein Substrate
- P-Glycoprotein Inhibition
- Preliminary BCS Permeability (non-GLP)
- Metabolite Identification (without structure elucidation)
Bioanalytical Services for Small Molecules (non-GLP)
- Method development
- Method Validation
- Bio-sample analysis