ACE (peptidyl-dipeptidase A) is a kind of zinc metallopeptidase, which plays an important role in blood-pressure control and water-salt metabolism. The widely expressed ACE shows the highest content in lung, kidney, heart, gastrointestinal system and prostate.
ACE has two main functions: 1. catalyze and convert angiotensin I into angiotensin II; 2. inactivate bradykinin. Thus, it's the suitable target for the treatment of hypertension, heart failure, diabetes mellitus type 2, diabetes and kidney diseases.
Currently, FineTest has developed the active ACE protein expressed by eukaryotic expression system and uses it in the related Elisa kit.
| Catalogue No.: | P8059 |
| Synonyms: | ACE, ACE1, Angiotensin converting enzyme, CD143, DCP, DCP1, Dipeptidyl carboxypeptidase I, Kininase II, MVCD3 |
| Species: | Human |
| Uniprot ID: | P12821 |
| Expression Region: | 30-1232 |
| Source: | HEK 293 cells |
| Tags: | C-terminal His Tag |
| Molecular Weight: | 140 kDa |
| Purity: | Greater than 95% by SDS-PAGE gel analyses |
| Activity: | Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK(Dnp)-OH (R&D Systems, Catalog # ES005). The specific activity is >1,000 pmol/min/µg, as measured under the described |
| Formulation: | Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose and 0.06% proclin, pH7.4 |
| Reconstitution: | Centrifuge the vial at 10,000 rpm for 1 minute, reconstitute at 200 μg/ml in sterile distilled water |
| Storage: | -20°C for 12 months as lyophilized; 2-8°C for 1 month under sterile conditions after reconstitution |
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Human ACE(Angiotensin I Converting Enzyme) ELISA Kit (EH0026)
Recombinant Human ACE2 (P2955)