Psoriatic arthritis

BASDAI tends to be higher in women while there is no appreciable difference in ASDAS scoring in men compared to women. Dr. L. Eder believes this could be due to the pain scoring in both indices. #RNL2024 @RheumNow @lihi_eder https://t.co/PSnFwX3eHu

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Dr. John Cush @RheumNow( View Tweet )

Dr. Eder at RNL

ICYMI: Sex Disparities in PsA/SpA

Kathryn H. Dao, M.D.

Dr. Eder delivered an illuminating talk at RheumNow Live 2024 on sex differences in psoriatic arthritis; the disease may manifest differently in men and women, and therapeutic responses may differ between the sexes.

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2018 ACR/National Psoarasis Foundation Guidelines for Treatment of PsA - Created helpful definitions of Severe PsA and Severe PsO #RNL2024 @RheumNow @AlexisOgdie https://t.co/mYOWNEevfW

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Dr. John Cush @RheumNow( View Tweet )

#RNL2024 @RheumNow @_AprilArmstrong Choosing a biologic in Psoriasis TNF - great in PsA, pregnancy. Avoid in demyelinating, hep B IL-17 - robust skin, PsA (axial too). Avoid in IBD IL-23 - robust skin, PsA evidence, fewer injections https://t.co/42kUaIZxKs

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Dr. John Cush @RheumNow( View Tweet )

April Armstrong RNL

ICYMI: Co-management of Psoriatic Disease

Richard Conway, MBBChBAO, PhD

It is a common clinical scenario to see someone with both severe psoriatic arthritis and skin psoriasis. In an ideal world this would involve a combined clinic with our local friendly dermatologist. For many of us, however, this is not practical for many reasons. The excellent Saturday morning

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vedolizumab-induced enthesitis @lihi_eder #RNL2024 @RheumNow 11/90 (12.2%) of pts on VDZ for IBD w/ develop new-onset enthesitis Is this true drug rxn or previously masked by prior meds (TNF)? Usually unilateral +/- oligo, dactylitis Most respond to NSAID or injxn, 27% change Rx

Dr. John Cush @RheumNow( View Tweet )

We're back on 4/9 with another Tuesday Night Rheumatology! We'll be focusing on PsA Hot Topics. Register to attend today! https://t.co/Ay0uxyfYDk https://t.co/QxZSI9EzTg

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Dr. John Cush @RheumNow( View Tweet )
RheumNow Podcast square

1/600 Falls May Die (4.5.2024)

Jack Cush, MD

Dr. Jack Cush reviews the news and Journal reports from this past week on RheumNow.com -  including problems w/ falls, pain and treatment of Dupuytren’s contractures.

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Psoriasis, arms, PsA

Mortality in Psoriatic Arthritis

Jack Cush, MD

The Annals of Rheumatic Disease reports that mortality risk in psoriatic arthritis (PsA) is about 10% higher than in the general population, primarily from excess comorbidity and with increased risks in women, with longer disease durations.

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There is world wide variability the prevalence of #PsA - the global prevalence=112 per 100K adults; and is more common in Europe (207/100K) and North America (64/100K) compared with Asia (37/100K) and South America https://t.co/UY25S00w26 https://t.co/AZMbZ3hG2c

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Dr. John Cush @RheumNow( View Tweet )
Epigenetics and Autoimmune Skin Disease The central dogma proposed that genetic information predominantly transfers from DNA to RNA during gene expression to make a functional product protein. https://t.co/VgQE2yYYmq https://t.co/fAWBifCyWv

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Dr. John Cush @RheumNow( View Tweet )
2023 EULAR Psoriatic Arthritis Recommendations EULAR has updated its treatment recommendations— The updated guidance includes 7 overarching principles and 11 recommendations regarding treatment strategy and pharmacological therapies. https://t.co/ja4g5I9emg https://t.co/9pxeup5ACg

Links:

Dr. John Cush @RheumNow( View Tweet )
FINAL 2020 Podcast Graphic

Activity & Pain Tolerance (3.29.2024)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com, including where you should sit in clinic and why you should worry about secondary Sjogren's in RA.

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Long term outcomes of phase III KEEPsAKE 2 trial in #PsA; SC risankizumab 150 mg given q12wks (after wk 24). 78% were ongoing. RZK achieved 60% ACR20 at wk 52, 57% ACR20 at wk 100, & 75% maintained ACR20 to wk 100. MDA achieved in 34% & 33%.https://t.co/juYQklrhG3 https://t.co/8uhmydPZDf

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Dr. John Cush @RheumNow( View Tweet )
pregnancy,embryo,fetal

Higher Rates of Childlessness in Rheumatic Diseases

Jack Cush, MD

A large Finnish population study shows that several rheumatic diseases may impair reproduction and pregnancy outcomes, with significantly higher rates of childlessness or fewer children overall for women.

A nationwide cohort study of 5 339 804 Finnish citizens, born 1964–1984,

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Window of Opportunity in Psoriatic Arthritis A Dutch Early Psoriatic Arthritis cohort study shows that psoriatic arthritis (PsA) patients treated early (referred and diagnosed within in less than 12 weeks) had the best clinical outcomes. https://t.co/mbftcq1dv8 https://t.co/VYNtByK9l0

Links:

Dr. John Cush @RheumNow( View Tweet )
2023 EULAR Psoriatic Arthritis Recommendations EULAR has updated its treatment recommendations— The updated guidance includes 7 overarching principles and 11 recommendations regarding treatment strategy and pharmacological therapies. https://t.co/0hofxzGX9O https://t.co/FXOgEJ0P0F

Links:

Dr. John Cush @RheumNow( View Tweet )
PsA, PSO, nail

Window of Opportunity in Psoriatic Arthritis

Jack Cush, MD

A Dutch Early Psoriatic Arthritis cohort study shows that psoriatic arthritis (PsA) patients treated early (referred and diagnosed  within in less than 12 weeks) had the best clinical outcomes. 

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Naysayers & Disrupters (3.22.2024)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week - including a few contrary reports on infection, seropositivity and plasmapheresis.

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Expert Panel Guidance on Managing Psoriatic Arthritis and Comorbidities An expert panel has published their consensus guidelines for the management of psoriatic arthritis (PsA) and it's comorbidities in the journal Rheumatology. https://t.co/pZjnW4dPxj https://t.co/Si9Gl3WgUx

Links:

Dr. John Cush @RheumNow( View Tweet )
guidelines.recommendations.jpg

2023 EULAR Psoriatic Arthritis Recommendations

Jack Cush, MD

EULAR has updated its treatment recommendations from the prior 2019 guidelines, since which there have been several newly developed agents. The updated guidance includes 7 overarching principles and 11 recommendations regarding treatment strategy and pharmacological therapies.

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French claims data study of Serious infections in 12K #PsA pts Rx w/ biologics (2015-2020) found 367 (3%) w/serious infxn (17/1000Pys). Compared to adalimumab, a signif. lower SIE risk was seen w/ ETN (HR 0.72), & ustekinumab (HR 0.57) https://t.co/oVomnKuYGJ https://t.co/y5DQatFoCa

Links:

Dr. John Cush @RheumNow( View Tweet )
PSA068.jpg

Expert Panel Guidance on Managing Psoriatic Arthritis and Comorbidities

Jack Cush, MD

An expert panel has published their consensus guidelines for the management of psoriatic arthritis (PsA) and it's comorbidities in the journal Rheumatology. 

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Long-term safety of Ixekizumab (IXE) - 26 RCTs (22k PYs) in PSO, PsA, AS & nr-axSpA - nasopharyngitis most common AE; AEs did not incr over time - D/C from AE 3-5/100Pys - ISRs: 5.9-11.6/100PYs - Candida 1.2-2/100PYs - IBD: 0.1 PsO - 0.8/100PY for axSpA https://t.co/nOoCE3VOxD https://t.co/F4gP1yR1Je

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Dr. John Cush @RheumNow( View Tweet )
Mixed Long-term Effects of Calcium and Vitamin D in Postmenopausal Women https://t.co/u2cf5hmTAE https://t.co/A4kdwG6eRm

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Dr. John Cush @RheumNow( View Tweet )

Recent Blogs

Best of 2022: The Enthesitis Challenge in Psoriatic Arthritis

Robert Chao, MD
heel enthesitis spur calcaneal
A colleague of mine once told me an interesting story of how her father, who was a doctor, misdiagnosed his wife with fibromyalgia when she actually had psoriatic arthritis with enthesitis all along. I would venture out and say that the average physician would have trouble evaluating enthesitis because even we, as rheumatologists do!  Read Post

Best of 2022: Toss of a Coin - How do You Choose PsA Medication?

M. Elaine Husni, MD, MPH
Coin toss
When balancing all these disease domains, individual phenotypes, and comorbidities, sometimes treatment decisions can feel like tossing a coin. Fortunately, numerous guidelines have been published to help us do better than tossing a coin…or do they?  Read Post

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