Modification of the natural
course of the disease
Induce remission or
prevention of relapse
Slow or stop clinical
progression of disease
Slow or stop progression of damage
Sustained improvement in disease
state, continuing after treatment
discontinuation
Disease outcomes
Disease manifestations
Relief or delay of clinical
signs and symptoms
- Disease activity
Improvement or normalization of:
- Physical function
- Quality of life
- Social and work capacity
Impact on the disease
pathophysiology